Successful Treatment of Primary Vaginal Papillary Serous Adenocarcinoma Using Chemoradiation Followed by Brachytherapy

• Main Authors: M. McCurdy, N. Zouain
• Format: Article
• Language: English
• Published: Karger Publishers 2009-06-01
• Series: Case Reports in Oncology
• Subjects: Cisplatin; Radiotherapy; Vaginal cancer; Adenocarcinoma; High-dose-rate brachytherapy
• Online Access: http://www.karger.com/Article/FullText/220818

Advances in treatment have not recently been reported in rare primary vaginal adenocarcinomas. A 56-year-old woman with a chronic vaginal cyst and possible in utero diethylstilbestrol exposure presented with postmenopausal bleeding. Biopsy of the vagina revealed high-grade papillary serous adenocarcinoma. MRI showed a 6-cm vaginal tumor and 3-cm left inguinal lymph node with metastasis. The patient initially received concurrent cisplatin and radiation. She then received high-dose-rate brachytherapy for further local control. Brachytherapy following external beam radiation with concurrent cisplatin led to clinically undetectable cancer at 24 months with minimal side effects.