Non-viral liposome-mediated transfer of brain-derived neurotrophic factor across the blood-brain barrier

Non-viral liposome-mediated transfer of brain-derived neurotrophic factor across the blood-brain barrier

Brain-derived neurotrophic factor (BDNF) plays an important role in the repair of central nervous system injury, but cannot directly traverse the blood-brain barrier. Liposomes are a new type of non-viral vector, able to carry macromolecules across the blood-brain barrier and into the brain. Here, w...

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Bibliographic Details
Main Authors: Ying Xing, Chun-yan Wen, Song-tao Li, Zong-xin Xia
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2016-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; brain injury; brain-derived neurotrophic factor; liposomes; targeting; vector; transfection; hippocampus; cortex; encapsulation efficiency; blood-brain barrier; transferrin; glial fibrillary acidic protein; polyethylene glycol; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=4;spage=617;epage=622;aulast=Xing

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