Hypoxia-induced preadipocyte factor 1 expression in human lung fibroblasts through ERK/PEA3/c-Jun pathway

Hypoxia-induced preadipocyte factor 1 expression in human lung fibroblasts through ERK/PEA3/c-Jun pathway

Abstract Background Several studies have reported that hypoxia plays a pathological role in severe asthma and tissue fibrosis. Our previous study showed that hypoxia induces A disintegrin and metalloproteinase 17 (ADAM17) expression in human lung fibroblasts. Moreover, preadipocyte factor 1 (Pref-1)...

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Bibliographic Details
Main Authors: Wun-Hao Cheng, Chia-Ling Chen, Jing-Yun Chen, Chien-Huang Lin, Bing-Chang Chen
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Molecular Medicine
Subjects:
Hypoxia
Pref-1
ERK
PEA3
AP-1
Human lung fibroblasts
Online Access:https://doi.org/10.1186/s10020-021-00336-w

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