A Link between Replicative Stress, Lamin Proteins, and Inflammation

A Link between Replicative Stress, Lamin Proteins, and Inflammation

Double-stranded breaks (DSB), the most toxic DNA lesions, are either a consequence of cellular metabolism, programmed as in during V(D)J recombination, or induced by anti-tumoral therapies or accidental genotoxic exposure. One origin of DSB sources is replicative stress, a major source of genome ins...

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Bibliographic Details
Main Authors: Simon Willaume, Emilie Rass, Paula Fontanilla-Ramirez, Angela Moussa, Paul Wanschoor, Pascale Bertrand
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Genes
Subjects:
DNA replication stress
lamins
Hutchinson-Gilford progeria syndrome
inflammation
senescence
aging
Online Access:https://www.mdpi.com/2073-4425/12/4/552

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