Impact of Subclinical Congestion on Outcome of Patients Undergoing Mitral Valve Surgery

• Main Authors: Anne-Kristin Schaefer, Thomas Poschner, Martin Andreas, Alfred Kocher, Günther Laufer, Dominik Wiedemann, Markus Mach
• Format: Article
• Language: English
• Published: MDPI AG 2020-09-01
• Series: Biomedicines
• Subjects: plasma volume; subclinical congestion; heart failure; cardiac decompensation
• Online Access: https://www.mdpi.com/2227-9059/8/9/363

Since risk assessment prior to cardiac surgery is based on proven but partly unsatisfactory scores, the need for novel tools in preoperative risk assessment taking into account cardiac decompensation is obvious. Even subclinical chronic heart failure is accompanied by an increase in plasma volume. This increase is illustrated by means of a plasma volume score (PVS), calculated using weight, gender and hematocrit. A retrospective analysis of 187 consecutive patients with impaired left ventricular function undergoing mitral valve surgery at a single centre between 2013 and 2016 was conducted. Relative preoperative PVS was generated by subtracting the ideal from actual calculated plasma volume. The study population was divided into two cohorts using a relative PVS score > 3.1 as cut-off. Patients with PVS > 3.1 had a significantly higher need for reoperation for bleeding/tamponade (5.5% vs. 16.7%; <i>p</i> = 0.016) and other non-cardiac causes (9.4% vs. 21.7%; <i>p</i> = 0.022). In-hospital as well as 6-month, 1-year and 5-year mortality was significantly increased in PVS > 3.1 (6.3% vs. 18.3%; <i>p</i> = 0.013; 9.4% vs. 23.3%; <i>p</i> = 0.011; 11.5% vs. 23.3%; <i>p</i> = 0.026; 18.1% vs. 33.3%; <i>p</i> = 0.018). Elevated PVS above the defined cut-off used to quantify subclinical congestion was linked to significantly worse outcome after mitral valve surgery and therefore could be a useful addition to current preoperative risk stratification.