Comparing the Efficacy of Sequential and Standard Quadruple Therapy for Eradication of H. Pylori Infection

• Main Authors: Mohsen Razavizadeh, Abbas Arj, Maryam Madani, Hamidreza Gilassi
• Format: Article
• Language: English
• Published: Karolinum Press 2020-01-01
• Series: Acta Medica
• Subjects: H. pylori infection; Sequential therapy; standard triple-drug therapy; eradication
• Online Access: https://actamedica.lfhk.cuni.cz/63/4/0183/
• ISSN: 1211-4286; 1805-9694

Background: The aim of this study was comparison the effectiveness of sequential and standard quadruple therapy on eradication of H. pylori infection. Methods: This clinical trial study was conducted on 160 patients with dyspepsia or gastroduodenal ulcer. Patients were randomly divided into two groups. Group A (standard regimen) received omeprazole, amoxicillin, clarithromycin and bismuth subcitrate for 2 weeks. Group B (sequential regimen) received omeprazole and amoxicillin in 5 days and omeprazole, tinidazole and levofloxacin in 5 days. After the end of treatment regimens, 20 mg omeprazole was administered twice daily for 3 weeks. H. pylori eradication was assessed 2 months after antibiotic treatment via fecal antigen. Results: Frequency of H. pylori eradication in group A and B was observed in 55 (68.8%) and 63 patients (78.8%), respectively. No significant difference was seen between two groups, regarding H. pylori eradication (p = 0.15). The most common side effects in group A, B were bitterness of mouth (63.8%) and nausea (16.2%), respectively (p H. pylori infection, higher rate of H. pylori eradication was seen in group B than group A. Thus, sequential regimen was a more appropriate regimen with fewer complications.