Targeting LAG-3 and PD-1 to Enhance T Cell Activation by Antigen-Presenting Cells

Targeting LAG-3 and PD-1 to Enhance T Cell Activation by Antigen-Presenting Cells

Immune checkpoint inhibition has been shown to successfully reactivate endogenous T cell responses directed against tumor-associated antigens, resulting in significantly prolonged overall survival in patients with various tumor entities. For malignancies with low endogenous immune responses, this ap...

Full description

Bibliographic Details
Main Authors: Felix S. Lichtenegger, Maurine Rothe, Frauke M. Schnorfeil, Katrin Deiser, Christina Krupka, Christian Augsberger, Miriam Schlüter, Julia Neitz, Marion Subklewe
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
cancer immunotherapy
dendritic cell
immune checkpoint molecules
LAG-3
PD-1
T cell response
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00385/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00385/full

Similar Items