DCAF1 controls T-cell function via p53-dependent and -independent mechanisms

DCAF1 controls T-cell function via p53-dependent and -independent mechanisms

DCAF1 (VprBP), an HIV target protein, is a component of an ubiquitin ligase complex involved in developmental processes in plants and animals. Here, DCAF1 is shown to be vital for activation-induced T cell growth and proliferation, partly by being required for p53’s ubiquitination and degradation.

Bibliographic Details
Main Authors: Zengli Guo, Qing Kong, Cui Liu, Song Zhang, Liyun Zou, Feng Yan, Jason K. Whitmire, Yue Xiong, Xian Chen, Yisong Y. Wan
Format: Article
Language:English
Published: Nature Publishing Group 2016-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10307

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