DCAF1 controls T-cell function via p53-dependent and -independent mechanisms

DCAF1 (VprBP), an HIV target protein, is a component of an ubiquitin ligase complex involved in developmental processes in plants and animals. Here, DCAF1 is shown to be vital for activation-induced T cell growth and proliferation, partly by being required for p53’s ubiquitination and degradation.

Bibliographic Details
Main Authors:	Zengli Guo, Qing Kong, Cui Liu, Song Zhang, Liyun Zou, Feng Yan, Jason K. Whitmire, Yue Xiong, Xian Chen, Yisong Y. Wan
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms10307

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spelling	doaj-e3ad2463a41e46ce80707481ab85705f2021-05-11T10:57:52ZengNature Publishing GroupNature Communications2041-17232016-01-017111310.1038/ncomms10307DCAF1 controls T-cell function via p53-dependent and -independent mechanismsZengli Guo0Qing Kong1Cui Liu2Song Zhang3Liyun Zou4Feng Yan5Jason K. Whitmire6Yue Xiong7Xian Chen8Yisong Y. Wan9Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel HillLineberger Comprehensive Cancer Center, University of North Carolina at Chapel HillLineberger Comprehensive Cancer Center, University of North Carolina at Chapel HillLineberger Comprehensive Cancer Center, University of North Carolina at Chapel HillLineberger Comprehensive Cancer Center, University of North Carolina at Chapel HillLineberger Comprehensive Cancer Center, University of North Carolina at Chapel HillDepartment of Genetics, University of North Carolina at Chapel HillLineberger Comprehensive Cancer Center, University of North Carolina at Chapel HillLineberger Comprehensive Cancer Center, University of North Carolina at Chapel HillLineberger Comprehensive Cancer Center, University of North Carolina at Chapel HillDCAF1 (VprBP), an HIV target protein, is a component of an ubiquitin ligase complex involved in developmental processes in plants and animals. Here, DCAF1 is shown to be vital for activation-induced T cell growth and proliferation, partly by being required for p53’s ubiquitination and degradation.https://doi.org/10.1038/ncomms10307
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Zengli Guo Qing Kong Cui Liu Song Zhang Liyun Zou Feng Yan Jason K. Whitmire Yue Xiong Xian Chen Yisong Y. Wan
spellingShingle	Zengli Guo Qing Kong Cui Liu Song Zhang Liyun Zou Feng Yan Jason K. Whitmire Yue Xiong Xian Chen Yisong Y. Wan DCAF1 controls T-cell function via p53-dependent and -independent mechanisms Nature Communications
author_facet	Zengli Guo Qing Kong Cui Liu Song Zhang Liyun Zou Feng Yan Jason K. Whitmire Yue Xiong Xian Chen Yisong Y. Wan
author_sort	Zengli Guo
title	DCAF1 controls T-cell function via p53-dependent and -independent mechanisms
title_short	DCAF1 controls T-cell function via p53-dependent and -independent mechanisms
title_full	DCAF1 controls T-cell function via p53-dependent and -independent mechanisms
title_fullStr	DCAF1 controls T-cell function via p53-dependent and -independent mechanisms
title_full_unstemmed	DCAF1 controls T-cell function via p53-dependent and -independent mechanisms
title_sort	dcaf1 controls t-cell function via p53-dependent and -independent mechanisms
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-01-01
description	DCAF1 (VprBP), an HIV target protein, is a component of an ubiquitin ligase complex involved in developmental processes in plants and animals. Here, DCAF1 is shown to be vital for activation-induced T cell growth and proliferation, partly by being required for p53’s ubiquitination and degradation.
url	https://doi.org/10.1038/ncomms10307
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DCAF1 controls T-cell function via p53-dependent and -independent mechanisms

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