Histological Changes in the Lung and Liver of Mice Treated with Brake Pad Particles

In the present study, the effects of brake pad particles of lung and liver histological sections were evaluated for (60) adult male mice. The animals were divided into three groups ( A,B,C) according to the periods of exposure (4, 8, and 12) weeks respectively exposed to brake pad particles in addi...

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Main Author: Ghaidan et al.
Format: Article
Language:Arabic
Published: College of Science for Women, University of Baghdad 2019-06-01
Series:Baghdad Science Journal
Subjects:
Online Access:http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/3461
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spelling doaj-e39e02af3b8348f48445f3c4f6c68aed2020-11-24T23:51:17ZaraCollege of Science for Women, University of BaghdadBaghdad Science Journal2078-86652411-79862019-06-0116210.21123/bsj.16.2.0306Histological Changes in the Lung and Liver of Mice Treated with Brake Pad ParticlesGhaidan et al. In the present study, the effects of brake pad particles of lung and liver histological sections were evaluated for (60) adult male mice. The animals were divided into three groups ( A,B,C) according to the periods of exposure (4, 8, and 12) weeks respectively exposed to brake pad particles in addition to the control groups (F) exposed to fresh air only. A special inhalation chamber designed locally has been used to expose the animals. The exposure to brake pad particles was (2.228) µg/m³ for 30 min/day, 5 days/week for (4,8and12) weeks respectively. The examination in group (A) of the histological sections of the lung showed the thickness of interalveolar septa.  Also, a congestion of alveolar capillary was marked indicating pulmonary emphysema. The infiltration of alveolar macrophages showed the engulfed foreign particles (pad particles) within their cytoplasm, and peribronchial fibrosis. Group (B) showed the presence of pad particles (anthracosis), whereas the bronchial tree showed bronchitis with the bronchus-hyperplasia of mucin-producing cells (epithelial hyperplasia). Still another section showed an infiltration of mononuclear leukocytes and focal lobar necrosis. The third group (C), in turn, revealed acute interstitial bronchopneumonia with peribronchial focal necrosis and mild pulmonary edema with alveolar anthracosis. As regards the liver, group (A) showed mild central venous congestion. Group (B), on the other hand, gave acute hepatitis, congestion of the central vein hyaline degeneration and mitotic figure having 2-3 nuclei. Severe congestion of the central vein with vascular amyloid deposition and most of the hepatocytes revealed coagulate necrosis in group (C). These changing tissues increased with increasing the exposure periods and were clearer in group (C) which was exposed for 12 weeks. The continuous exposure to brake pad particles lead to damaging important body organs tissues and effect on human health, these particles can be considered as a type of pollutants added to air pollutants in different cities of Iraq.   http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/3461Brake pad particles, Heavy metals, Liver, Lung, Non-exhaust emission.
collection DOAJ
language Arabic
format Article
sources DOAJ
author Ghaidan et al.
spellingShingle Ghaidan et al.
Histological Changes in the Lung and Liver of Mice Treated with Brake Pad Particles
Baghdad Science Journal
Brake pad particles, Heavy metals, Liver, Lung, Non-exhaust emission.
author_facet Ghaidan et al.
author_sort Ghaidan et al.
title Histological Changes in the Lung and Liver of Mice Treated with Brake Pad Particles
title_short Histological Changes in the Lung and Liver of Mice Treated with Brake Pad Particles
title_full Histological Changes in the Lung and Liver of Mice Treated with Brake Pad Particles
title_fullStr Histological Changes in the Lung and Liver of Mice Treated with Brake Pad Particles
title_full_unstemmed Histological Changes in the Lung and Liver of Mice Treated with Brake Pad Particles
title_sort histological changes in the lung and liver of mice treated with brake pad particles
publisher College of Science for Women, University of Baghdad
series Baghdad Science Journal
issn 2078-8665
2411-7986
publishDate 2019-06-01
description In the present study, the effects of brake pad particles of lung and liver histological sections were evaluated for (60) adult male mice. The animals were divided into three groups ( A,B,C) according to the periods of exposure (4, 8, and 12) weeks respectively exposed to brake pad particles in addition to the control groups (F) exposed to fresh air only. A special inhalation chamber designed locally has been used to expose the animals. The exposure to brake pad particles was (2.228) µg/m³ for 30 min/day, 5 days/week for (4,8and12) weeks respectively. The examination in group (A) of the histological sections of the lung showed the thickness of interalveolar septa.  Also, a congestion of alveolar capillary was marked indicating pulmonary emphysema. The infiltration of alveolar macrophages showed the engulfed foreign particles (pad particles) within their cytoplasm, and peribronchial fibrosis. Group (B) showed the presence of pad particles (anthracosis), whereas the bronchial tree showed bronchitis with the bronchus-hyperplasia of mucin-producing cells (epithelial hyperplasia). Still another section showed an infiltration of mononuclear leukocytes and focal lobar necrosis. The third group (C), in turn, revealed acute interstitial bronchopneumonia with peribronchial focal necrosis and mild pulmonary edema with alveolar anthracosis. As regards the liver, group (A) showed mild central venous congestion. Group (B), on the other hand, gave acute hepatitis, congestion of the central vein hyaline degeneration and mitotic figure having 2-3 nuclei. Severe congestion of the central vein with vascular amyloid deposition and most of the hepatocytes revealed coagulate necrosis in group (C). These changing tissues increased with increasing the exposure periods and were clearer in group (C) which was exposed for 12 weeks. The continuous exposure to brake pad particles lead to damaging important body organs tissues and effect on human health, these particles can be considered as a type of pollutants added to air pollutants in different cities of Iraq.  
topic Brake pad particles, Heavy metals, Liver, Lung, Non-exhaust emission.
url http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/3461
work_keys_str_mv AT ghaidanetal histologicalchangesinthelungandliverofmicetreatedwithbrakepadparticles
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