Accurate immune repertoire sequencing reveals malaria infection driven antibody lineage diversification in young children

Somatic hypermutation of antibodies can occur in infants but are difficult to track. Here the authors present a new method called MIDCIRS for deep quantitative repertoire sequencing with few cells, and show infants as young as 3 months can expand antibody lineage complexity in response to malaria in...

Full description

Bibliographic Details
Main Authors:	Ben S. Wendel, Chenfeng He, Mingjuan Qu, Di Wu, Stefany M. Hernandez, Ke-Yue Ma, Eugene W. Liu, Jun Xiao, Peter D. Crompton, Susan K. Pierce, Pengyu Ren, Keke Chen, Ning Jiang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-00645-x

id	doaj-e3859fc7336a44ffae74cb5a14acbd04
record_format	Article
spelling	doaj-e3859fc7336a44ffae74cb5a14acbd042021-05-11T07:32:48ZengNature Publishing GroupNature Communications2041-17232017-09-018111410.1038/s41467-017-00645-xAccurate immune repertoire sequencing reveals malaria infection driven antibody lineage diversification in young childrenBen S. Wendel0Chenfeng He1Mingjuan Qu2Di Wu3Stefany M. Hernandez4Ke-Yue Ma5Eugene W. Liu6Jun Xiao7Peter D. Crompton8Susan K. Pierce9Pengyu Ren10Keke Chen11Ning Jiang12McKetta Department of Chemical Engineering, Cockrell School of Engineering, University of Texas at AustinDepartment of Biomedical engineering, Cockrell School of Engineering, University of Texas at AustinDepartment of Biomedical engineering, Cockrell School of Engineering, University of Texas at AustinDepartment of Biomedical engineering, Cockrell School of Engineering, University of Texas at AustinMcKetta Department of Chemical Engineering, Cockrell School of Engineering, University of Texas at AustinInstitute for Cellular and Molecular Biology, College of Natural Sciences, University of Texas at AustinLaboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of HealthImmuDX, LLCLaboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of HealthLaboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of HealthDepartment of Biomedical engineering, Cockrell School of Engineering, University of Texas at AustinDepartment of Computer Science and Engineering, Wright State UniversityDepartment of Biomedical engineering, Cockrell School of Engineering, University of Texas at AustinSomatic hypermutation of antibodies can occur in infants but are difficult to track. Here the authors present a new method called MIDCIRS for deep quantitative repertoire sequencing with few cells, and show infants as young as 3 months can expand antibody lineage complexity in response to malaria infection.https://doi.org/10.1038/s41467-017-00645-x
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ben S. Wendel Chenfeng He Mingjuan Qu Di Wu Stefany M. Hernandez Ke-Yue Ma Eugene W. Liu Jun Xiao Peter D. Crompton Susan K. Pierce Pengyu Ren Keke Chen Ning Jiang
spellingShingle	Ben S. Wendel Chenfeng He Mingjuan Qu Di Wu Stefany M. Hernandez Ke-Yue Ma Eugene W. Liu Jun Xiao Peter D. Crompton Susan K. Pierce Pengyu Ren Keke Chen Ning Jiang Accurate immune repertoire sequencing reveals malaria infection driven antibody lineage diversification in young children Nature Communications
author_facet	Ben S. Wendel Chenfeng He Mingjuan Qu Di Wu Stefany M. Hernandez Ke-Yue Ma Eugene W. Liu Jun Xiao Peter D. Crompton Susan K. Pierce Pengyu Ren Keke Chen Ning Jiang
author_sort	Ben S. Wendel
title	Accurate immune repertoire sequencing reveals malaria infection driven antibody lineage diversification in young children
title_short	Accurate immune repertoire sequencing reveals malaria infection driven antibody lineage diversification in young children
title_full	Accurate immune repertoire sequencing reveals malaria infection driven antibody lineage diversification in young children
title_fullStr	Accurate immune repertoire sequencing reveals malaria infection driven antibody lineage diversification in young children
title_full_unstemmed	Accurate immune repertoire sequencing reveals malaria infection driven antibody lineage diversification in young children
title_sort	accurate immune repertoire sequencing reveals malaria infection driven antibody lineage diversification in young children
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-09-01
description	Somatic hypermutation of antibodies can occur in infants but are difficult to track. Here the authors present a new method called MIDCIRS for deep quantitative repertoire sequencing with few cells, and show infants as young as 3 months can expand antibody lineage complexity in response to malaria infection.
url	https://doi.org/10.1038/s41467-017-00645-x
work_keys_str_mv	AT benswendel accurateimmunerepertoiresequencingrevealsmalariainfectiondrivenantibodylineagediversificationinyoungchildren AT chenfenghe accurateimmunerepertoiresequencingrevealsmalariainfectiondrivenantibodylineagediversificationinyoungchildren AT mingjuanqu accurateimmunerepertoiresequencingrevealsmalariainfectiondrivenantibodylineagediversificationinyoungchildren AT diwu accurateimmunerepertoiresequencingrevealsmalariainfectiondrivenantibodylineagediversificationinyoungchildren AT stefanymhernandez accurateimmunerepertoiresequencingrevealsmalariainfectiondrivenantibodylineagediversificationinyoungchildren AT keyuema accurateimmunerepertoiresequencingrevealsmalariainfectiondrivenantibodylineagediversificationinyoungchildren AT eugenewliu accurateimmunerepertoiresequencingrevealsmalariainfectiondrivenantibodylineagediversificationinyoungchildren AT junxiao accurateimmunerepertoiresequencingrevealsmalariainfectiondrivenantibodylineagediversificationinyoungchildren AT peterdcrompton accurateimmunerepertoiresequencingrevealsmalariainfectiondrivenantibodylineagediversificationinyoungchildren AT susankpierce accurateimmunerepertoiresequencingrevealsmalariainfectiondrivenantibodylineagediversificationinyoungchildren AT pengyuren accurateimmunerepertoiresequencingrevealsmalariainfectiondrivenantibodylineagediversificationinyoungchildren AT kekechen accurateimmunerepertoiresequencingrevealsmalariainfectiondrivenantibodylineagediversificationinyoungchildren AT ningjiang accurateimmunerepertoiresequencingrevealsmalariainfectiondrivenantibodylineagediversificationinyoungchildren
_version_	1721452076343492608

Accurate immune repertoire sequencing reveals malaria infection driven antibody lineage diversification in young children

Similar Items