Accurate immune repertoire sequencing reveals malaria infection driven antibody lineage diversification in young children
Somatic hypermutation of antibodies can occur in infants but are difficult to track. Here the authors present a new method called MIDCIRS for deep quantitative repertoire sequencing with few cells, and show infants as young as 3 months can expand antibody lineage complexity in response to malaria in...
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Bibliographic Details
| Main Authors: |
Ben S. Wendel,
Chenfeng He,
Mingjuan Qu,
Di Wu,
Stefany M. Hernandez,
Ke-Yue Ma,
Eugene W. Liu,
Jun Xiao,
Peter D. Crompton,
Susan K. Pierce,
Pengyu Ren,
Keke Chen,
Ning Jiang |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2017-09-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-017-00645-x
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