Glucocorticosteroids in nano-sterically stabilized liposomes are efficacious for elimination of the acute symptoms of experimental cerebral malaria.

Cerebral malaria is the most severe complication of Plasmodium falciparum infection, and a leading cause of death in children under the age of five in malaria-endemic areas. We report high therapeutic efficacy of a novel formulation of liposome-encapsulated water-soluble glucocorticoid prodrugs, and...

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Main Authors: Judith H Waknine-Grinberg, Simcha Even-Chen, Jasmine Avichzer, Keren Turjeman, Annael Bentura-Marciano, Richard K Haynes, Lola Weiss, Nahum Allon, Haim Ovadia, Jacob Golenser, Yechezkel Barenholz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3753236?pdf=render