Synthesis of Triptorelin Lactate Catalyzed by Lipase in Organic Media

Synthesis of Triptorelin Lactate Catalyzed by Lipase in Organic Media

Triptorelin lactate was successfully synthesized by porcine pancreatic lipase (PPL)<em> </em>in organic solvents. The effects of acyl donor, substrate ratio, organic solvent, temperature, and water activity were investigated. Under the optimum conditions, a yield of 30% f...

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Main Authors: Hong Zhuang, Zhi Wang, Jiaxin Wang, Hong Zhang, Erna Xun, Ge Chen, Hong Yue, Ning Tang, Lei Wang
Format: Article
Language:English
Published: MDPI AG 2012-08-01
Series:International Journal of Molecular Sciences
Subjects:
triptorelin lactate
lipase
enzyme activity
esterification
Online Access:http://www.mdpi.com/1422-0067/13/8/9971
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spelling doaj-e381d85a6912443e9d85dfb2a751c1772020-11-24T21:55:35ZengMDPI AGInternational Journal of Molecular Sciences1422-00672012-08-011389971997910.3390/ijms13089971Synthesis of Triptorelin Lactate Catalyzed by Lipase in Organic MediaHong ZhuangZhi WangJiaxin WangHong ZhangErna XunGe ChenHong YueNing TangLei WangTriptorelin lactate was successfully synthesized by porcine pancreatic lipase (PPL)<em> </em>in organic solvents. The effects of acyl donor, substrate ratio, organic solvent, temperature, and water activity were investigated. Under the optimum conditions, a yield of 30% for its ester could be achieved in the reaction for about 48 h.http://www.mdpi.com/1422-0067/13/8/9971triptorelin lactatelipaseenzyme activityesterification
collection DOAJ
language English
format Article
sources DOAJ
author Hong Zhuang
Zhi Wang
Jiaxin Wang
Hong Zhang
Erna Xun
Ge Chen
Hong Yue
Ning Tang
Lei Wang
spellingShingle Hong Zhuang
Zhi Wang
Jiaxin Wang
Hong Zhang
Erna Xun
Ge Chen
Hong Yue
Ning Tang
Lei Wang
Synthesis of Triptorelin Lactate Catalyzed by Lipase in Organic Media
International Journal of Molecular Sciences
triptorelin lactate
lipase
enzyme activity
esterification
author_facet Hong Zhuang
Zhi Wang
Jiaxin Wang
Hong Zhang
Erna Xun
Ge Chen
Hong Yue
Ning Tang
Lei Wang
author_sort Hong Zhuang
title Synthesis of Triptorelin Lactate Catalyzed by Lipase in Organic Media
title_short Synthesis of Triptorelin Lactate Catalyzed by Lipase in Organic Media
title_full Synthesis of Triptorelin Lactate Catalyzed by Lipase in Organic Media
title_fullStr Synthesis of Triptorelin Lactate Catalyzed by Lipase in Organic Media
title_full_unstemmed Synthesis of Triptorelin Lactate Catalyzed by Lipase in Organic Media
title_sort synthesis of triptorelin lactate catalyzed by lipase in organic media
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1422-0067
publishDate 2012-08-01
description Triptorelin lactate was successfully synthesized by porcine pancreatic lipase (PPL)<em> </em>in organic solvents. The effects of acyl donor, substrate ratio, organic solvent, temperature, and water activity were investigated. Under the optimum conditions, a yield of 30% for its ester could be achieved in the reaction for about 48 h.
topic triptorelin lactate
lipase
enzyme activity
esterification
url http://www.mdpi.com/1422-0067/13/8/9971
work_keys_str_mv AT hongzhuang synthesisoftriptorelinlactatecatalyzedbylipaseinorganicmedia
AT zhiwang synthesisoftriptorelinlactatecatalyzedbylipaseinorganicmedia
AT jiaxinwang synthesisoftriptorelinlactatecatalyzedbylipaseinorganicmedia
AT hongzhang synthesisoftriptorelinlactatecatalyzedbylipaseinorganicmedia
AT ernaxun synthesisoftriptorelinlactatecatalyzedbylipaseinorganicmedia
AT gechen synthesisoftriptorelinlactatecatalyzedbylipaseinorganicmedia
AT hongyue synthesisoftriptorelinlactatecatalyzedbylipaseinorganicmedia
AT ningtang synthesisoftriptorelinlactatecatalyzedbylipaseinorganicmedia
AT leiwang synthesisoftriptorelinlactatecatalyzedbylipaseinorganicmedia
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