The Role of Angiogenesis in Human Non-Hodgkin Lymphomas

The role of angiogenesis in the growth of lymphomas and survival of patients with leukemias and other hematological malignancies has become evident since 1994. Angiogenic factors, such as vascular endothelial growth factor and its receptors together with other tumor microenvironment components, inc...

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Main Authors: Domenico Ribatti, Beatrice Nico, Girolamo Ranieri, Giorgina Specchia, Angelo Vacca
Format: Article
Language:English
Published: Elsevier 2013-03-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S147655861380053X
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spelling doaj-e37935be562a46e78d0de80555fe9af52020-11-25T00:55:21ZengElsevierNeoplasia: An International Journal for Oncology Research1476-55861522-80022013-03-0115323123810.1593/neo.121962The Role of Angiogenesis in Human Non-Hodgkin LymphomasDomenico Ribatti0Beatrice Nico1Girolamo Ranieri2Giorgina Specchia3Angelo Vacca4Department of Basic Medical Sciences, Neurosciences and Sensory Organs, Section of Human Anatomy and Histology, University of Bari Medical School, Bari, ItalyDepartment of Basic Medical Sciences, Neurosciences and Sensory Organs, Section of Human Anatomy and Histology, University of Bari Medical School, Bari, ItalyNational Cancer Institute “Giovanni Paolo II”, Bari, ItalyDepartment of Emergency and Transplantation, Hematology Section, University of Bari Medical School, Bari, ItalyDepartment of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy The role of angiogenesis in the growth of lymphomas and survival of patients with leukemias and other hematological malignancies has become evident since 1994. Angiogenic factors, such as vascular endothelial growth factor and its receptors together with other tumor microenvironment components, including myelo-monocytic cell, mast cells, endothelial progenitor cells, and circulating endothelial cells, have been shown to be important in the progression and maintenance of lymphoproliferative disorders. In this review article, we present an overview of the literature focusing on the relationship between angiogenesis and disease progression and the recent advantages in the antiangiogenic treatment in human non-Hodgkin lymphomas. http://www.sciencedirect.com/science/article/pii/S147655861380053X
collection DOAJ
language English
format Article
sources DOAJ
author Domenico Ribatti
Beatrice Nico
Girolamo Ranieri
Giorgina Specchia
Angelo Vacca
spellingShingle Domenico Ribatti
Beatrice Nico
Girolamo Ranieri
Giorgina Specchia
Angelo Vacca
The Role of Angiogenesis in Human Non-Hodgkin Lymphomas
Neoplasia: An International Journal for Oncology Research
author_facet Domenico Ribatti
Beatrice Nico
Girolamo Ranieri
Giorgina Specchia
Angelo Vacca
author_sort Domenico Ribatti
title The Role of Angiogenesis in Human Non-Hodgkin Lymphomas
title_short The Role of Angiogenesis in Human Non-Hodgkin Lymphomas
title_full The Role of Angiogenesis in Human Non-Hodgkin Lymphomas
title_fullStr The Role of Angiogenesis in Human Non-Hodgkin Lymphomas
title_full_unstemmed The Role of Angiogenesis in Human Non-Hodgkin Lymphomas
title_sort role of angiogenesis in human non-hodgkin lymphomas
publisher Elsevier
series Neoplasia: An International Journal for Oncology Research
issn 1476-5586
1522-8002
publishDate 2013-03-01
description The role of angiogenesis in the growth of lymphomas and survival of patients with leukemias and other hematological malignancies has become evident since 1994. Angiogenic factors, such as vascular endothelial growth factor and its receptors together with other tumor microenvironment components, including myelo-monocytic cell, mast cells, endothelial progenitor cells, and circulating endothelial cells, have been shown to be important in the progression and maintenance of lymphoproliferative disorders. In this review article, we present an overview of the literature focusing on the relationship between angiogenesis and disease progression and the recent advantages in the antiangiogenic treatment in human non-Hodgkin lymphomas.
url http://www.sciencedirect.com/science/article/pii/S147655861380053X
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