PIK3CA Gene Mutations in Solid Malignancies: Association with Clinicopathological Parameters and Prognosis

PIK3CA Gene Mutations in Solid Malignancies: Association with Clinicopathological Parameters and Prognosis

Phosphoinositide kinases (PIKs) are a group of lipid kinases that are important upstream activators of various significant signaling pathways. Hyperactivation of the PI3K/AKT/mTOR pathways—either via mutations or genomic amplification—confers key oncogenic activity, essential for...

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Bibliographic Details
Main Authors: Ali Alqahtani, Hazem S. K. Ayesh, Hafez Halawani
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Cancers
Subjects:
solid malignancy
<i>pik3ca</i>
mutation
overall survival
pi3k/akt/mtor pathway
Online Access:https://www.mdpi.com/2072-6694/12/1/93

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