Heme Oxygenase 1 in the Nervous System: Does It Favor Neuronal Cell Survival or Induce Neurodegeneration?
Heme oxygenase 1 (HO-1) up-regulation is recognized as a pivotal mechanism of cell adaptation to stress. Under control of different transcription factors but with a prominent role played by Nrf2, HO-1 induction is crucial also in nervous system response to damage. However, several lines of evidence...
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MDPI AG
2018-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/19/8/2260 |
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doaj-e36e1b5573a24b6dbaee17cb68325cad2020-11-24T22:15:42ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-08-01198226010.3390/ijms19082260ijms19082260Heme Oxygenase 1 in the Nervous System: Does It Favor Neuronal Cell Survival or Induce Neurodegeneration?Mariapaola Nitti0Sabrina Piras1Lorenzo Brondolo2Umberto Maria Marinari3Maria Adelaide Pronzato4Anna Lisa Furfaro5Department of Experimental Medicine, University of Genoa, Via L.B.Alberti 2, 16132 Genoa, ItalyDepartment of Experimental Medicine, University of Genoa, Via L.B.Alberti 2, 16132 Genoa, ItalyDepartment of Experimental Medicine, University of Genoa, Via L.B.Alberti 2, 16132 Genoa, ItalyDepartment of Experimental Medicine, University of Genoa, Via L.B.Alberti 2, 16132 Genoa, ItalyDepartment of Experimental Medicine, University of Genoa, Via L.B.Alberti 2, 16132 Genoa, ItalyDepartment of Experimental Medicine, University of Genoa, Via L.B.Alberti 2, 16132 Genoa, ItalyHeme oxygenase 1 (HO-1) up-regulation is recognized as a pivotal mechanism of cell adaptation to stress. Under control of different transcription factors but with a prominent role played by Nrf2, HO-1 induction is crucial also in nervous system response to damage. However, several lines of evidence have highlighted that HO-1 expression is associated to neuronal damage and neurodegeneration especially in Alzheimer’s and Parkinson’s diseases. In this review, we summarize the current literature regarding the role of HO-1 in nervous system pointing out different molecular mechanisms possibly responsible for HO-1 up-regulation in nervous system homeostasis and neurodegeneration.http://www.mdpi.com/1422-0067/19/8/2260HO-1oxidative stresscarbon monoxidebilirubinnervous systemneurodegenerationAlzheimer’s diseaseParkinson’s diseaseischemia/reperfusion injurytraumatic brain injury |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Mariapaola Nitti Sabrina Piras Lorenzo Brondolo Umberto Maria Marinari Maria Adelaide Pronzato Anna Lisa Furfaro |
| spellingShingle |
Mariapaola Nitti Sabrina Piras Lorenzo Brondolo Umberto Maria Marinari Maria Adelaide Pronzato Anna Lisa Furfaro Heme Oxygenase 1 in the Nervous System: Does It Favor Neuronal Cell Survival or Induce Neurodegeneration? International Journal of Molecular Sciences HO-1 oxidative stress carbon monoxide bilirubin nervous system neurodegeneration Alzheimer’s disease Parkinson’s disease ischemia/reperfusion injury traumatic brain injury |
| author_facet |
Mariapaola Nitti Sabrina Piras Lorenzo Brondolo Umberto Maria Marinari Maria Adelaide Pronzato Anna Lisa Furfaro |
| author_sort |
Mariapaola Nitti |
| title |
Heme Oxygenase 1 in the Nervous System: Does It Favor Neuronal Cell Survival or Induce Neurodegeneration? |
| title_short |
Heme Oxygenase 1 in the Nervous System: Does It Favor Neuronal Cell Survival or Induce Neurodegeneration? |
| title_full |
Heme Oxygenase 1 in the Nervous System: Does It Favor Neuronal Cell Survival or Induce Neurodegeneration? |
| title_fullStr |
Heme Oxygenase 1 in the Nervous System: Does It Favor Neuronal Cell Survival or Induce Neurodegeneration? |
| title_full_unstemmed |
Heme Oxygenase 1 in the Nervous System: Does It Favor Neuronal Cell Survival or Induce Neurodegeneration? |
| title_sort |
heme oxygenase 1 in the nervous system: does it favor neuronal cell survival or induce neurodegeneration? |
| publisher |
MDPI AG |
| series |
International Journal of Molecular Sciences |
| issn |
1422-0067 |
| publishDate |
2018-08-01 |
| description |
Heme oxygenase 1 (HO-1) up-regulation is recognized as a pivotal mechanism of cell adaptation to stress. Under control of different transcription factors but with a prominent role played by Nrf2, HO-1 induction is crucial also in nervous system response to damage. However, several lines of evidence have highlighted that HO-1 expression is associated to neuronal damage and neurodegeneration especially in Alzheimer’s and Parkinson’s diseases. In this review, we summarize the current literature regarding the role of HO-1 in nervous system pointing out different molecular mechanisms possibly responsible for HO-1 up-regulation in nervous system homeostasis and neurodegeneration. |
| topic |
HO-1 oxidative stress carbon monoxide bilirubin nervous system neurodegeneration Alzheimer’s disease Parkinson’s disease ischemia/reperfusion injury traumatic brain injury |
| url |
http://www.mdpi.com/1422-0067/19/8/2260 |
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