Oligomeric state of the ZIKV E protein defines protective immune responses

Oligomeric state of the ZIKV E protein defines protective immune responses

Many human antibodies that neutralize Zika virus recognize quaternary epitopes on the envelope (E) protein. Here, Metz et al. engineer stable recombinant homodimers of Zika virus E protein and show that it induces neutralizing antibodies in mice that recognize similar epitopes as human antibodies fr...

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Bibliographic Details
Main Authors: Stefan W. Metz, Ashlie Thomas, Alex Brackbill, John Forsberg, Michael J. Miley, Cesar A. Lopez, Helen M. Lazear, Shaomin Tian, Aravinda M. de Silva
Format: Article
Language:English
Published: Nature Publishing Group 2019-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12677-6

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