Oligomeric state of the ZIKV E protein defines protective immune responses

Many human antibodies that neutralize Zika virus recognize quaternary epitopes on the envelope (E) protein. Here, Metz et al. engineer stable recombinant homodimers of Zika virus E protein and show that it induces neutralizing antibodies in mice that recognize similar epitopes as human antibodies fr...

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Main Authors:	Stefan W. Metz, Ashlie Thomas, Alex Brackbill, John Forsberg, Michael J. Miley, Cesar A. Lopez, Helen M. Lazear, Shaomin Tian, Aravinda M. de Silva
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-12677-6

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spelling	doaj-e36de0074bf54f54a8a6e3c49a2d13232021-05-11T11:29:10ZengNature Publishing GroupNature Communications2041-17232019-10-011011710.1038/s41467-019-12677-6Oligomeric state of the ZIKV E protein defines protective immune responsesStefan W. Metz0Ashlie Thomas1Alex Brackbill2John Forsberg3Michael J. Miley4Cesar A. Lopez5Helen M. Lazear6Shaomin Tian7Aravinda M. de Silva8Department of Microbiology and Immunology, University of North Carolina at Chapel HillDepartment of Microbiology and Immunology, University of North Carolina at Chapel HillDepartment of Pharmacology, University of North Carolina at Chapel HillDepartment of Pharmacology, University of North Carolina at Chapel HillDepartment of Pharmacology, University of North Carolina at Chapel HillDepartment of Microbiology and Immunology, University of North Carolina at Chapel HillDepartment of Microbiology and Immunology, University of North Carolina at Chapel HillDepartment of Microbiology and Immunology, University of North Carolina at Chapel HillDepartment of Microbiology and Immunology, University of North Carolina at Chapel HillMany human antibodies that neutralize Zika virus recognize quaternary epitopes on the envelope (E) protein. Here, Metz et al. engineer stable recombinant homodimers of Zika virus E protein and show that it induces neutralizing antibodies in mice that recognize similar epitopes as human antibodies from Zika infected people.https://doi.org/10.1038/s41467-019-12677-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Stefan W. Metz Ashlie Thomas Alex Brackbill John Forsberg Michael J. Miley Cesar A. Lopez Helen M. Lazear Shaomin Tian Aravinda M. de Silva
spellingShingle	Stefan W. Metz Ashlie Thomas Alex Brackbill John Forsberg Michael J. Miley Cesar A. Lopez Helen M. Lazear Shaomin Tian Aravinda M. de Silva Oligomeric state of the ZIKV E protein defines protective immune responses Nature Communications
author_facet	Stefan W. Metz Ashlie Thomas Alex Brackbill John Forsberg Michael J. Miley Cesar A. Lopez Helen M. Lazear Shaomin Tian Aravinda M. de Silva
author_sort	Stefan W. Metz
title	Oligomeric state of the ZIKV E protein defines protective immune responses
title_short	Oligomeric state of the ZIKV E protein defines protective immune responses
title_full	Oligomeric state of the ZIKV E protein defines protective immune responses
title_fullStr	Oligomeric state of the ZIKV E protein defines protective immune responses
title_full_unstemmed	Oligomeric state of the ZIKV E protein defines protective immune responses
title_sort	oligomeric state of the zikv e protein defines protective immune responses
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-10-01
description	Many human antibodies that neutralize Zika virus recognize quaternary epitopes on the envelope (E) protein. Here, Metz et al. engineer stable recombinant homodimers of Zika virus E protein and show that it induces neutralizing antibodies in mice that recognize similar epitopes as human antibodies from Zika infected people.
url	https://doi.org/10.1038/s41467-019-12677-6
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Oligomeric state of the ZIKV E protein defines protective immune responses

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