3'UTR-mediated gene silencing of the Mixed Lineage Leukemia (MLL) gene.

3'UTR-mediated gene silencing of the Mixed Lineage Leukemia (MLL) gene.

Translocations involving the Mixed Lineage Leukemia (MLL) gene generate in-frame fusions of MLL with more than 50 different partner genes (PGs). Common to all MLL translocations is the exchange not only of coding regions, but also of MLL and PG 3'-untranslated regions (3'UTRs). As a result...

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Bibliographic Details
Main Authors: Maria Gomez-Benito, Fabricio Loayza-Puch, Joachim A F Oude Vrielink, Maria D Odero, Reuven Agami
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3187771?pdf=render

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