Breast Cancer Brain Metastasis—Overview of Disease State, Treatment Options and Future Perspectives

Breast Cancer Brain Metastasis—Overview of Disease State, Treatment Options and Future Perspectives

Breast cancer is the second most common origin of brain metastasis after lung cancer. Brain metastasis in breast cancer is commonly found in patients with advanced course disease and has a poor prognosis because the blood–brain barrier is thought to be a major obstacle to the delivery of many drugs...

Full description

Bibliographic Details
Main Authors:	Chikashi Watase, Sho Shiino, Tatsunori Shimoi, Emi Noguchi, Tomoya Kaneda, Yusuke Yamamoto, Kan Yonemori, Shin Takayama, Akihiko Suto
Format:	Article
Language:	English
Published:	MDPI AG 2021-03-01
Series:	Cancers
Subjects:	central nervous system blood–brain barrier neurosurgery stereotactic radiosurgery (SRS) whole brain radiation therapy (WBRT) molecular-targeted therapy
Online Access:	https://www.mdpi.com/2072-6694/13/5/1078

Similar Items

Are brain metastases curable? Case report and a brief review of the literature
by: Juan Enrique Gutierrez Valencia, et al.
Published: (2019-01-01)

The Expanding Role of Radiosurgery for Brain Metastases
by: Mark O’Beirn, et al.
Published: (2018-08-01)

Whole Brain Radiation Therapy Plus Stereotactic Radiosurgery in the Treatment of Brain Metastases Leading to Improved Survival in Patients With Favorable Prognostic Factors
by: Muhammad Khan, et al.
Published: (2019-03-01)

Current Multimodality Treatments Against Brain Metastases from Renal Cell Carcinoma
by: Yoshiyuki Matsui
Published: (2020-10-01)

Repeated Courses of Radiosurgery for New Brain Metastases to Defer Whole Brain Radiotherapy: Feasibility and Outcome With Validation of the New Prognostic Metric Brain Metastasis Velocity
by: Corinna Fritz, et al.
Published: (2018-11-01)

Tumor Primary Site and Histology Subtypes Role in Radiotherapeutic Management of Brain Metastases
by: Muhammad Khan, et al.
Published: (2020-07-01)

Frameless Image-Guided Radiosurgery for Multiple Brain Metastasis Using VMAT: A Review and an Institutional Experience
by: Samir Abdallah Hanna, et al.
Published: (2019-08-01)

Outcomes of re-irradiation for brain recurrence after prophylactic or therapeutic whole-brain irradiation for small cell lung Cancer: a retrospective analysis
by: Ryoko Suzuki, et al.
Published: (2018-12-01)

Whole brain radiation therapy plus focal boost may be a suitable strategy for brain metastases in SCLC patients: a multi-center study
by: Meng Ni, et al.
Published: (2020-03-01)

Long-term Outcomes after Salvage Stereotactic Radiosurgery (SRS) following In-Field Failure of Initial SRS for Brain Metastases
by: Nitesh Rana, et al.
Published: (2017-11-01)

Contemporary Management of 1–4 Brain Metastases
by: Sarah M. C. Sittenfeld, et al.
Published: (2018-09-01)

Sector Irradiation vs. Whole Brain Irradiation After Resection of Singular Brain Metastasis—A Prospective Randomized Monocentric Trial
by: Johannes Kerschbaumer, et al.
Published: (2020-11-01)

Treatment of Brain Metastasis from Lung Cancer
by: Alexander Chi, et al.
Published: (2010-12-01)

Strategies to Preserve Cognition in Patients With Brain Metastases: A Review
by: Tyler P. Robin, et al.
Published: (2018-10-01)

Preoperative Stereotactic Radiosurgery for Brain Metastases
by: David M. Routman, et al.
Published: (2018-11-01)

BRAF Mutation is Associated with Improved Local Control of Melanoma Brain Metastases Treated with Gamma Knife Radiosurgery
by: Ian S Gallaher, et al.
Published: (2016-05-01)

FSRT vs. SRS in Brain Metastases—Differences in Local Control and Radiation Necrosis—A Volumetric Study
by: Florian Putz, et al.
Published: (2020-09-01)

Treatment patterns and outcomes among women with brain metastases from gynecologic malignancies
by: Kristen Cagino, et al.
Published: (2020-11-01)

Prevention of Brain Metastases
by: Joseph A. Bovi
Published: (2018-09-01)

Treatment of brain metastases
by: Marcel Matzenauer, et al.
Published: (2016-12-01)

Pre-Operative Versus Post-Operative Radiosurgery of Brain Metastases—Volumetric and Dosimetric Impact of Treatment Sequence and Margin Concept
by: Rami A. El Shafie, et al.
Published: (2019-03-01)

Systemic Therapy after Radiotherapy Significantly Reduces the Risk of Mortality of Patients with 1–3 Brain Metastases: A Retrospective Study of 250 Patients
by: Bo Li, et al.
Published: (2017-01-01)

Single Institutional Experience of Stereotactic Radiosurgery Alone for First Brain Metastatic Event and Salvage of Second Brain Metastatic Event in a Community Setting with Review of the Literature
by: Shaharyar Ahmad, et al.
Published: (2017-03-01)

Which Prognostic Index is Most Appropriate in the Setting of Delayed Stereotactic Radiosurgery for Brain Metastases?
by: Timothy Malouff, et al.
Published: (2016-11-01)

Stereotactic Radiosurgery With Concurrent Immunotherapy in Melanoma Brain Metastases Is Feasible and Effective
by: Jakob Liermann, et al.
Published: (2020-10-01)

Integration of Systemic Therapy and Stereotactic Radiosurgery for Brain Metastases
by: Raees Tonse, et al.
Published: (2021-07-01)

Single isocenter treatment planning techniques for stereotactic radiosurgery of multiple cranial metastases
by: Christian Velten, et al.
Published: (2021-01-01)

Stereotactic radiosurgery for intracranial metastases from gastrointestinal malignancies: a retrospective analysis
by: Fazal, Muhammad
Published: (2016)

Robotic Stereotactic Radiosurgery in Melanoma Patients with Brain Metastases under Simultaneous Anti-PD-1 Treatment
by: Maike Trommer-Nestler, et al.
Published: (2018-09-01)

Immunotherapy Combined with Large Fractions of Radiotherapy: Stereotactic Radiosurgery for Brain Metastases—Implications for Intraoperative Radiotherapy after Resection
by: Carsten Herskind, et al.
Published: (2017-07-01)

Risk factors for local failure requiring salvage neurosurgery after radiosurgery for brain metastases
by: Wladimir Nadalin, et al.
Published: (2004-06-01)

Evaluation of brain edema formation defined by MRI after LINAC-based stereotactic radiosurgery
by: Harat Maciej, et al.
Published: (2017-05-01)

The individual risk of symptomatic radionecrosis after brain metastasis radiosurgery is predicted by a continuous function of the V12Gy
by: Jean-François Daisne, et al.
Published: (2021-03-01)

A case of long-term disease control in a patient with disseminated melanoma with synchronous detection of multiple brain metastases
by: M. I. Kurzhupov
Published: (2018-12-01)

Dosimetric Performance and Planning/Delivery Efficiency of a Dual-Layer Stacked and Staggered MLC on Treating Multiple Small Targets: A Planning Study Based on Single-Isocenter Multi-Target Stereotactic Radiosurgery (SRS) to Brain Metastases
by: Taoran Li, et al.
Published: (2019-01-01)

Stereotactic radiosurgery combined with nivolumab or Ipilimumab for patients with melanoma brain metastases: evaluation of brain control and toxicity
by: Giuseppe Minniti, et al.
Published: (2019-04-01)

A Single-Institution Analysis of 126 Patients Treated with Stereotactic Radiosurgery for Brain Metastases
by: Kevin B. Harris, et al.
Published: (2017-05-01)

Whole-Brain Radiation Therapy With Simultaneous Integrated Boost Versus Whole-Brain Radiation Therapy Plus Stereotactic Radiosurgery for the Treatment of Brain Metastasis From Lung Cancer
by: Binwei Lin, et al.
Published: (2021-03-01)

Physician self-reported treatment of brain metastases according to patients’ clinical and demographic factors and physician practice setting
by: Kress Marie-Adele S, et al.
Published: (2012-11-01)

Combination of anti-PD-1 therapy and stereotactic radiosurgery for a gastric cancer patient with brain metastasis: a case report
by: Min-joo Ahn, et al.
Published: (2018-02-01)