Oncogenic H-Ras up-regulates acid β-hexosaminidase by a mechanism dependent on the autophagy regulator TFEB.

Oncogenic H-Ras up-regulates acid β-hexosaminidase by a mechanism dependent on the autophagy regulator TFEB.

The expression of constitutively active H-RasV12 oncogene has been described to induce proliferative arrest and premature senescence in many cell models. There are a number of studies indicating an association between senescence and lysosomal enzyme alterations, e.g. lysosomal β-galactosidase is the...

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Bibliographic Details
Main Authors: Lorena Urbanelli, Alessandro Magini, Luisa Ercolani, Krizia Sagini, Alice Polchi, Brunella Tancini, Alessandro Brozzi, Tatiana Armeni, Giovanni Principato, Carla Emiliani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24586816/pdf/?tool=EBI

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