Ancestry and TPMT-VNTR Polymorphism: Relationship with Hematological Toxicity in Uruguayan Patients with Acute Lymphoblastic Leukemia

Ancestry and TPMT-VNTR Polymorphism: Relationship with Hematological Toxicity in Uruguayan Patients with Acute Lymphoblastic Leukemia

6-Mercaptopurine (6-MP) is a thiopurine drug widely used in childhood acute lymphoblastic leukemia (ALL) therapy. Genes such as TPMT and NUDT15 have an outstanding role in 6-MP metabolism. Mutations in both genes explain a significant portion of hematological toxicities suffered by ALL Uruguayan ped...

Full description

Bibliographic Details
Main Authors: Gabriela Burgueño-Rodríguez, Yessika Méndez, Natalia Olano, Agustín Dabezies, Bernardo Bertoni, Jorge Souto, Luis Castillo, Julio da Luz, Ana María Soler
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Pharmacology
Subjects:
Acute Lymphoblastic Leukemia
TPMT
TPMT-VNTR
NUDT15
6-MP
Pharmacogenomics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.594262/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.594262/full

Similar Items