Inhibition of Pannexin 1 Reduces the Tumorigenic Properties of Human Melanoma Cells

Inhibition of Pannexin 1 Reduces the Tumorigenic Properties of Human Melanoma Cells

Pannexin 1 (PANX1) is a channel-forming glycoprotein expressed in many tissues including the skin. PANX1 channels allow the passage of ions and molecules up to 1 kDa, including ATP and other metabolites. In this study, we show that PANX1 is highly expressed in human melanoma tumors at all stages of...

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Bibliographic Details
Main Authors: Taylor J. Freeman, Samar Sayedyahossein, Danielle Johnston, Rafael E. Sanchez-Pupo, Brooke O’Donnell, Kenneth Huang, Zameena Lakhani, Daniel Nouri-Nejad, Kevin J. Barr, Luke Harland, Steven Latosinsky, Aaron Grant, Lina Dagnino, Silvia Penuela
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Cancers
Subjects:
pannexin
PANX1
melanoma
carbenoxolone
probenecid
tumor growth
patient-derived cells
Chick-CAM
xenografts
ATP
Wnt
β-catenin
Online Access:http://www.mdpi.com/2072-6694/11/1/102

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