Sensorineural hearing loss may lead to dementia-related pathological changes in hippocampal neurons

• Main Authors: Yilin Shen, Haixia Hu, Cui Fan, Quan Wang, Tianyuan Zou, Bin Ye, Mingliang Xiang
• Format: Article
• Language: English
• Published: Elsevier 2021-08-01
• Series: Neurobiology of Disease
• Subjects: Sensorineural hearing loss; Cognitive dysfunction; Neurogenesis; Phosphorylated tau; Inflammatory cytokines
• Online Access: http://www.sciencedirect.com/science/article/pii/S0969996121001571

Presbycusis contributes to cognitive decline and Alzheimer's disease. However, most research in this area involves clinical observations and statistical modeling, and few studies have examined the relationship between hearing loss and the molecular changes that lead to cognitive dysfunction. The present study investigated whether hearing loss contributes to dementia in the absence of aging and noise using a mouse model of severe bilateral hearing loss induced by kanamycin (1000 mg/kg) and furosemide (400 mg/kg). Immunohistochemistry, silver staining, immunofluorescence analysis, and Western blotting were used to observe pathological changes in different regions of the hippocampus in animals with hearing loss. Changes in the cognitive function of animals with hearing loss were assessed using the Morris water maze test. The results showed that neurons began to degenerate 60 days after hearing loss, and this degeneration was accompanied by structural disorganization and decreased neurogenesis. The level of phosphorylated tau increased over time. Increases in escape latency and distance traveled during the training phase of the Morris water maze test were observed 90 days after hearing loss. Activated microglia and astrocytes with increased levels of inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) were detected in the hippocampus. These results suggest that hearing loss alone causes neuronal degeneration, inhibition of neurogenesis, increased tau protein phosphorylation, and increased neuroinflammation in the hippocampus. Early intervention in individuals with hearing loss may reduce the risk of cognitive decline.