Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments

Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments

<p>Abstract</p> <p>The aim of this project was to compare cerium oxide and silver particles of different sizes for their potential for uptake by aquatic species, human exposure via ingestion of contaminated food sources and to assess their resultant toxicity. The results demonstrat...

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Main Authors: Tyler Charles R, Lead Jamie R, Jepson Mark, Fernandes Teresa F, Gaiser Birgit K, Stone Vicki
Format: Article
Language:English
Published: BMC 2009-12-01
Series:Environmental Health
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spelling doaj-e349bfedaf26489e9cfa72b65fe08dd32020-11-24T22:43:29ZengBMCEnvironmental Health1476-069X2009-12-018Suppl 1S210.1186/1476-069X-8-S1-S2Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environmentsTyler Charles RLead Jamie RJepson MarkFernandes Teresa FGaiser Birgit KStone Vicki<p>Abstract</p> <p>The aim of this project was to compare cerium oxide and silver particles of different sizes for their potential for uptake by aquatic species, human exposure via ingestion of contaminated food sources and to assess their resultant toxicity. The results demonstrate the potential for uptake of nano and larger particles by fish via the gastrointestinal tract, and by human intestinal epithelial cells, therefore suggesting that ingestion is a viable route of uptake into different organism types. A consistency was also shown in the sensitivity of aquatic, fish cell and human cell models to Ag and CeO<sub>2 </sub>particles of different sizes; with the observed sensitivity sequence from highest to lowest as: nano-Ag > micro Ag > nano CeO<sub>2 </sub>= micro CeO<sub>2</sub>. Such consistency suggests that further studies might allow extrapolation of results between different models and species.</p>
collection DOAJ
language English
format Article
sources DOAJ
author Tyler Charles R
Lead Jamie R
Jepson Mark
Fernandes Teresa F
Gaiser Birgit K
Stone Vicki
spellingShingle Tyler Charles R
Lead Jamie R
Jepson Mark
Fernandes Teresa F
Gaiser Birgit K
Stone Vicki
Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments
Environmental Health
author_facet Tyler Charles R
Lead Jamie R
Jepson Mark
Fernandes Teresa F
Gaiser Birgit K
Stone Vicki
author_sort Tyler Charles R
title Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments
title_short Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments
title_full Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments
title_fullStr Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments
title_full_unstemmed Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments
title_sort assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments
publisher BMC
series Environmental Health
issn 1476-069X
publishDate 2009-12-01
description <p>Abstract</p> <p>The aim of this project was to compare cerium oxide and silver particles of different sizes for their potential for uptake by aquatic species, human exposure via ingestion of contaminated food sources and to assess their resultant toxicity. The results demonstrate the potential for uptake of nano and larger particles by fish via the gastrointestinal tract, and by human intestinal epithelial cells, therefore suggesting that ingestion is a viable route of uptake into different organism types. A consistency was also shown in the sensitivity of aquatic, fish cell and human cell models to Ag and CeO<sub>2 </sub>particles of different sizes; with the observed sensitivity sequence from highest to lowest as: nano-Ag > micro Ag > nano CeO<sub>2 </sub>= micro CeO<sub>2</sub>. Such consistency suggests that further studies might allow extrapolation of results between different models and species.</p>
work_keys_str_mv AT tylercharlesr assessingexposureuptakeandtoxicityofsilverandceriumdioxidenanoparticlesfromcontaminatedenvironments
AT leadjamier assessingexposureuptakeandtoxicityofsilverandceriumdioxidenanoparticlesfromcontaminatedenvironments
AT jepsonmark assessingexposureuptakeandtoxicityofsilverandceriumdioxidenanoparticlesfromcontaminatedenvironments
AT fernandesteresaf assessingexposureuptakeandtoxicityofsilverandceriumdioxidenanoparticlesfromcontaminatedenvironments
AT gaiserbirgitk assessingexposureuptakeandtoxicityofsilverandceriumdioxidenanoparticlesfromcontaminatedenvironments
AT stonevicki assessingexposureuptakeandtoxicityofsilverandceriumdioxidenanoparticlesfromcontaminatedenvironments
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