Is There any Alternative Receptor for SARS-CoV-2?
Angiotensin-converting enzyme II (ACE2) in association with type II transmembrane serine protease (TMPRSS2) is considered the main receptor of SARS-CoV-2. However, considering the clinical complications of COVID-19 in different organs, there is no strong association between the abundance of ACE2/...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Royan Institute (ACECR), Tehran
2021-07-01
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| Series: | Cell Journal |
| Subjects: | |
| Online Access: | https://celljournal.org/journal/article/fulltext/grp78-an-alternative-receptor-for-sars-cov-2.pdf |
| Summary: | Angiotensin-converting enzyme II (ACE2) in association with type II transmembrane serine protease (TMPRSS2) is
considered the main receptor of SARS-CoV-2. However, considering the clinical complications of COVID-19 in different
organs, there is no strong association between the abundance of ACE2/TMPRSS2 co-expression and clinical features
of the disease and the severity of complications. Since SARS-CoV-2 affects certain organs that lack or have low
expression of ACE2/TMPRSS2, it may be possible that the virus employs other receptors for colonization and entry.
Based on recent studies, glucose-regulated protein 78 (GRP78) can be a potential alternative receptor for SARS-CoV-2
entry. In this letter, supporting evidence proposed GRP78 as an alternative receptor in SARS-CoV-2 infection. |
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| ISSN: | 2228-5806 2228-5814 |