The mucosal adjuvant cyclic di-AMP exerts immune stimulatory effects on dendritic cells and macrophages.

The mucosal adjuvant cyclic di-AMP exerts immune stimulatory effects on dendritic cells and macrophages.

The cyclic di-nucleotide bis-(3',5')-cyclic dimeric adenosine monophosphate (c-di-AMP) is a candidate mucosal adjuvant with proven efficacy in preclinical models. It was shown to promote specific humoral and cellular immune responses following mucosal administration. To date, there is only...

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Bibliographic Details
Main Authors: Ivana Škrnjug, Christine Rueckert, Rimma Libanova, Stefan Lienenklaus, Siegfried Weiss, Carlos A Guzmán
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3996008?pdf=render

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