Extended release granisetron: Review of pharmacologic considerations and clinical role in the perioperative setting

• Main Authors: Anh L Ngo, Vwaire Orhurhu, Ivan Urits, Edwin O Delfin, Medha Sharma, Mark R Jones, Omar Viswanath, Richard D Urman
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2019-01-01
• Series: Saudi Journal of Anaesthesia
• Subjects: 5-HT3 antagonists; anti-emetics; pharmacotherapy; post-operative nausea and vomiting
• Online Access: http://www.saudija.org/article.asp?issn=1658-354X;year=2019;volume=13;issue=3;spage=231;epage=236;aulast=Ngo
• ISSN: 1658-354X

In this review, we evaluate recent literature on use of ER granisetron in clinical practice as compared with current antiemetics and describe its potential uses for perioperative PONV prophylaxis and treatment. Recent literature was evaluated on ER granisetron use compared with currently used antiemetic agents ondansetron, droperidol, metoclopramide, promethazine, and dexamethasone with a focus on procedural anti-emesis. Though promising great effect, application of extended release granisetron to clinical use may be limited by it's increased relative cost.