IL-4 type 1 receptor signaling up-regulates KCNN4 expression, and increases the KCa3.1 current and its contribution to migration of alternative-activated microglia

IL-4 type 1 receptor signaling up-regulates KCNN4 expression, and increases the KCa3.1 current and its contribution to migration of alternative-activated microglia

The Ca2+-activated K+ channel, KCa3.1 (KCNN4/IK1/SK4), contributes to ‘classical’, pro-inflammatory activation of microglia, and KCa3.1 blockers have improved the outcome in several rodent models of CNS damage. For instance, blocking KCa3.1 with TRAM-34 rescued retinal ganglion neurons after optic n...

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Bibliographic Details
Main Authors: Roger eFerreira, Starlee eLively, Lyanne eSchlichter
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
alternative microglial activation
AP-1 transcription factor
KCa3.1/SK4 channel
IL-4 signaling
M2 macrophage activation
microglial migration
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00183/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00183/full

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