A Novel Joint Gene Set Analysis Framework Improves Identification of Enriched Pathways in Cross Disease Transcriptomic Analysis

A Novel Joint Gene Set Analysis Framework Improves Identification of Enriched Pathways in Cross Disease Transcriptomic Analysis

Motivation: Gene set enrichment analysis is a widely accepted expression analysis tool which aims at detecting coordinated expression change within a pre-defined gene sets rather than individual genes. The benefit of gene set analysis over individual differentially expressed (DE) gene analysis inclu...

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Bibliographic Details
Main Authors: Wenyi Qin, Xujun Wang, Hongyu Zhao, Hui Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Genetics
Subjects:
public data integration
cross disease transcriptome
gene expression
gene set enrichment analysis
mixture model
EM algorithm
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00293/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.00293/full

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