Biological process activity transformation of single cell gene expression for cross-species alignment

Biological process activity transformation of single cell gene expression for cross-species alignment

Single cell RNA-Seq data can report on cellular types and states, but low signal-to noise and sparse data can make interpretation of cellular state difficult. Here the authors propose a transformation strategy to map RNA-Seq data to biological process activities that are species-agnostic and allow f...

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Bibliographic Details
Main Authors: Hongxu Ding, Andrew Blair, Ying Yang, Joshua M. Stuart
Format: Article
Language:English
Published: Nature Publishing Group 2019-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12924-w
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spelling doaj-e32e60d474f14311b3573e25cb1cad5f2021-05-11T11:47:21ZengNature Publishing GroupNature Communications2041-17232019-10-011011610.1038/s41467-019-12924-wBiological process activity transformation of single cell gene expression for cross-species alignmentHongxu Ding0Andrew Blair1Ying Yang2Joshua M. Stuart3Santa Cruz Genomics Institute and Department of Biomolecular Engineering, University of CaliforniaSanta Cruz Genomics Institute and Department of Biomolecular Engineering, University of CaliforniaDepartment of Genetics and Development, Columbia University Medical CenterSanta Cruz Genomics Institute and Department of Biomolecular Engineering, University of CaliforniaSingle cell RNA-Seq data can report on cellular types and states, but low signal-to noise and sparse data can make interpretation of cellular state difficult. Here the authors propose a transformation strategy to map RNA-Seq data to biological process activities that are species-agnostic and allow for comparison across species.https://doi.org/10.1038/s41467-019-12924-w
collection DOAJ
language English
format Article
sources DOAJ
author Hongxu Ding
Andrew Blair
Ying Yang
Joshua M. Stuart
spellingShingle Hongxu Ding
Andrew Blair
Ying Yang
Joshua M. Stuart
Biological process activity transformation of single cell gene expression for cross-species alignment
Nature Communications
author_facet Hongxu Ding
Andrew Blair
Ying Yang
Joshua M. Stuart
author_sort Hongxu Ding
title Biological process activity transformation of single cell gene expression for cross-species alignment
title_short Biological process activity transformation of single cell gene expression for cross-species alignment
title_full Biological process activity transformation of single cell gene expression for cross-species alignment
title_fullStr Biological process activity transformation of single cell gene expression for cross-species alignment
title_full_unstemmed Biological process activity transformation of single cell gene expression for cross-species alignment
title_sort biological process activity transformation of single cell gene expression for cross-species alignment
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-10-01
description Single cell RNA-Seq data can report on cellular types and states, but low signal-to noise and sparse data can make interpretation of cellular state difficult. Here the authors propose a transformation strategy to map RNA-Seq data to biological process activities that are species-agnostic and allow for comparison across species.
url https://doi.org/10.1038/s41467-019-12924-w
work_keys_str_mv AT hongxuding biologicalprocessactivitytransformationofsinglecellgeneexpressionforcrossspeciesalignment
AT andrewblair biologicalprocessactivitytransformationofsinglecellgeneexpressionforcrossspeciesalignment
AT yingyang biologicalprocessactivitytransformationofsinglecellgeneexpressionforcrossspeciesalignment
AT joshuamstuart biologicalprocessactivitytransformationofsinglecellgeneexpressionforcrossspeciesalignment
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