Clinical Utility and Limitation of Diagnostic Ability for Different Degrees of Dysplasia of Intraductal Papillary Mucinous Neoplasms of the Pancreas Using ¹⁸F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography

• Main Authors: Yuto Hozaka, Hiroshi Kurahara, Hideyuki Oi, Tetsuya Idichi, Yoichi Yamasaki, Yota Kawasaki, Kiyonori Tanoue, Megumi Jinguji, Masatoyo Nakajo, Atsushi Tani, Akihiro Nakajo, Yuko Mataki, Yoshihiko Fukukura, Hirotsugu Noguchi, Michiyo Higashi, Takashi Yoshiura, Akihide Tanimoto, Takao Ohtsuka
• Format: Article
• Language: English
• Published: MDPI AG 2021-09-01
• Series: Cancers
• Subjects: IPMN; FDG; PET; mural nodule; high-grade dysplasia; glucose transporter 1
• Online Access: https://www.mdpi.com/2072-6694/13/18/4633

The diagnostic value of ¹⁸F-fluorodeoxyglucose (FDG) uptake in the management of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas remains unclear. This study aimed to assess the role of FDG uptake in the diagnosis of different degrees of dysplasia of IPMNs. We retrospectively analyzed the following three points in 84 patients with IPMNs: (1) risk factors to predict high-grade dysplasia (HGD) and invasive carcinoma (INV); (2) the relationship between FDG uptake and glucose transporter 1 (GLUT-1) expression; and (3) the relationship between FDG uptake and the presence of mural nodules. The histopathological diagnosis was low-grade dysplasia (LGD) in 43 patients, HGD in 16, and INV in 25. The maximum standardized uptake value (SUV-max) was significantly higher in INV than in LGD/HGD (<i>p</i> < 0.0001, <i>p</i> = 0.0136). The sensitivity and specificity to discriminate INV from LGD/HGD were 80.0% and 86.2%, respectively, using the receiver operator characteristic curve, when the optimal cutoff score of SUV-max was set at 4.03. Those values were not different between HGD and LGD. More than half of HGD patients had low GLUT-1 expression. Taken together, FDG-PET/CT is useful in distinguishing between non-invasive and invasive IPMN. Our results offer critical information that may determine surgical treatment strategies.