Mechanisms of Regulation of the Chemokine-Receptor Network

The interactions of chemokines with their G protein-coupled receptors promote the migration of leukocytes during normal immune function and as a key aspect of the inflammatory response to tissue injury or infection. This review summarizes the major cellular and biochemical mechanisms by which the in...

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Main Authors:	Martin J. Stone, Jenni A. Hayward, Cheng Huang, Zil E. Huma, Julie Sanchez
Format:	Article
Language:	English
Published:	MDPI AG 2017-02-01
Series:	International Journal of Molecular Sciences
Subjects:	chemokine chemokine receptor regulation binding expression glycosaminoglycan post-translational modification oligomerization signaling inhibitor
Online Access:	http://www.mdpi.com/1422-0067/18/2/342

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spelling	doaj-e300fd06d42a41aca0ac5b27327ea12c2020-11-24T21:53:02ZengMDPI AGInternational Journal of Molecular Sciences1422-00672017-02-0118234210.3390/ijms18020342ijms18020342Mechanisms of Regulation of the Chemokine-Receptor NetworkMartin J. Stone0Jenni A. Hayward1Cheng Huang2Zil E. Huma3Julie Sanchez4Infection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, AustraliaInfection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, AustraliaInfection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, AustraliaInfection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, AustraliaInfection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, AustraliaThe interactions of chemokines with their G protein-coupled receptors promote the migration of leukocytes during normal immune function and as a key aspect of the inflammatory response to tissue injury or infection. This review summarizes the major cellular and biochemical mechanisms by which the interactions of chemokines with chemokine receptors are regulated, including: selective and competitive binding interactions; genetic polymorphisms; mRNA splice variation; variation of expression, degradation and localization; down-regulation by atypical (decoy) receptors; interactions with cell-surface glycosaminoglycans; post-translational modifications; oligomerization; alternative signaling responses; and binding to natural or pharmacological inhibitors.http://www.mdpi.com/1422-0067/18/2/342chemokinechemokine receptorregulationbindingexpressionglycosaminoglycanpost-translational modificationoligomerizationsignalinginhibitor
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Martin J. Stone Jenni A. Hayward Cheng Huang Zil E. Huma Julie Sanchez
spellingShingle	Martin J. Stone Jenni A. Hayward Cheng Huang Zil E. Huma Julie Sanchez Mechanisms of Regulation of the Chemokine-Receptor Network International Journal of Molecular Sciences chemokine chemokine receptor regulation binding expression glycosaminoglycan post-translational modification oligomerization signaling inhibitor
author_facet	Martin J. Stone Jenni A. Hayward Cheng Huang Zil E. Huma Julie Sanchez
author_sort	Martin J. Stone
title	Mechanisms of Regulation of the Chemokine-Receptor Network
title_short	Mechanisms of Regulation of the Chemokine-Receptor Network
title_full	Mechanisms of Regulation of the Chemokine-Receptor Network
title_fullStr	Mechanisms of Regulation of the Chemokine-Receptor Network
title_full_unstemmed	Mechanisms of Regulation of the Chemokine-Receptor Network
title_sort	mechanisms of regulation of the chemokine-receptor network
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1422-0067
publishDate	2017-02-01
description	The interactions of chemokines with their G protein-coupled receptors promote the migration of leukocytes during normal immune function and as a key aspect of the inflammatory response to tissue injury or infection. This review summarizes the major cellular and biochemical mechanisms by which the interactions of chemokines with chemokine receptors are regulated, including: selective and competitive binding interactions; genetic polymorphisms; mRNA splice variation; variation of expression, degradation and localization; down-regulation by atypical (decoy) receptors; interactions with cell-surface glycosaminoglycans; post-translational modifications; oligomerization; alternative signaling responses; and binding to natural or pharmacological inhibitors.
topic	chemokine chemokine receptor regulation binding expression glycosaminoglycan post-translational modification oligomerization signaling inhibitor
url	http://www.mdpi.com/1422-0067/18/2/342
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Mechanisms of Regulation of the Chemokine-Receptor Network

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