Deciphering the stepwise binding mode of HRG1β to HER3 by surface plasmon resonance and interaction map.

Deciphering the stepwise binding mode of HRG1β to HER3 by surface plasmon resonance and interaction map.

For the development of efficient anti-cancer therapeutics against the HER receptor family it is indispensable to understand the mechanistic model of the HER receptor activation upon ligand binding. Due to its high complexity the binding mode of Heregulin 1 beta (HRG1β) with its receptor HER3 is so f...

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Bibliographic Details
Main Authors: Carmen Peess, Leopold von Proff, Sabine Goller, Karl Andersson, Michael Gerg, Magnus Malmqvist, Birgit Bossenmaier, Michael Schräml
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4319926?pdf=render

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