Inhibition of the Lipid Droplet–Peroxisome Proliferator-Activated Receptor α Axis Suppresses Cancer Stem Cell Properties

Inhibition of the Lipid Droplet–Peroxisome Proliferator-Activated Receptor α Axis Suppresses Cancer Stem Cell Properties

Cancer stem cells (CSCs), having both self-renewal and tumorigenic capacity, utilize an energy metabolism system different from that of non-CSCs. Lipid droplets (LDs) are organelles that store neutral lipids, including triacylglycerol. Previous studies demonstrated that LDs are formed and store lipi...

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Bibliographic Details
Main Authors: Kenta Kuramoto, Masahiro Yamamoto, Shuhei Suzuki, Keita Togashi, Tomomi Sanomachi, Chifumi Kitanaka, Masashi Okada
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Genes
Subjects:
peroxisome proliferator-activated receptor
cancer-initiating cell
lipid droplet
pancreatic cancer
colorectal cancer
re-esterification
Online Access:https://www.mdpi.com/2073-4425/12/1/99

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