A Capped Peptide of the Aggregation Prone NAC 71–82 Amino Acid Stretch of α-Synuclein Folds into Soluble β-Sheet Oligomers at Low and Elevated Peptide Concentrations

A Capped Peptide of the Aggregation Prone NAC 71–82 Amino Acid Stretch of α-Synuclein Folds into Soluble β-Sheet Oligomers at Low and Elevated Peptide Concentrations

Although Lewy bodies and Lewy neurites are hallmarks of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), misfolded α-synuclein oligomers are nowadays believed to be key for the development of these diseases. Attempts to target soluble misfolded species of the full-len...

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Bibliographic Details
Main Authors: Thomas Näsström, Jörgen Ådén, Fumina Shibata, Per Ola Andersson, Björn C.G. Karlsson
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
α-synuclein
capped nac 71–82 peptide
soluble β-sheet oligomers
circular dichroism spectroscopy
molecular dynamics simulations
thioflavin t fluorescence
Online Access:https://www.mdpi.com/1422-0067/21/5/1629

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