Targeting Endothelin-1 Receptor/β-Arrestin-1 Axis in Ovarian Cancer: From Basic Research to a Therapeutic Approach

Targeting Endothelin-1 Receptor/β-Arrestin-1 Axis in Ovarian Cancer: From Basic Research to a Therapeutic Approach

Recent studies imply a key role of endothelin-1 receptor (ET-1R), belonging to the largest family of G protein-coupled receptors (GPCR), in the regulation of a plethora of processes involved in tumorigenesis and metastatic progression. β-arrestin-1 (β-arr1) system has been recognized as a critical h...

Full description

Bibliographic Details
Main Authors: Piera Tocci, Laura Rosanò, Anna Bagnato
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Endocrinology
Subjects:
endothelin-1
endothelin-1 receptors
ovarian cancer
β-arrestin-1
G-protein coupled receptors
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00609/full

Similar Items

Similar Items