Altered GluN2B NMDA receptor function and synaptic plasticity during early pathology in the PS2APP mouse model of Alzheimer's disease

Altered GluN2B NMDA receptor function and synaptic plasticity during early pathology in the PS2APP mouse model of Alzheimer's disease

GluN2B subunit containing NMDARs (GluN2B-NMDARs) mediate pathophysiological effects of acutely applied amyloid beta (Aβ), including impaired long-term potentiation (LTP). However, in transgenic Alzheimer's disease (AD) mouse models which feature gradual Aβ accumulation, the function of GluN2B-N...

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Bibliographic Details
Main Authors: Jesse E. Hanson, Jean-Francois Pare, Lunbin Deng, Yoland Smith, Qiang Zhou
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Neurobiology of Disease
Subjects:
NMDA receptor
GluN2B
NR2B
PS2APP
Alzheimer's disease
Synaptic plasticity
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114003635

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http://www.sciencedirect.com/science/article/pii/S0969996114003635

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