Post-transcriptional dysregulation by miRNAs is implicated in the pathogenesis of gastrointestinal stromal tumor [GIST].

Post-transcriptional dysregulation by miRNAs is implicated in the pathogenesis of gastrointestinal stromal tumor [GIST].

In contrast to adult mutant gastrointestinal stromal tumors [GISTs], pediatric/wild-type GISTs remain poorly understood overall, given their lack of oncogenic activating tyrosine kinase mutations. These GISTs, with a predilection for gastric origin in female patients, show limited response to therap...

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Main Authors: Lorna Kelly, Kenneth Bryan, Su Young Kim, Katherine A Janeway, J Keith Killian, Hans-Ulrich Schildhaus, Markku Miettinen, Lee Helman, Paul S Meltzer, Matt van de Rijn, Maria Debiec-Rychter, Maureen O'Sullivan, NIH Pediatric and Wild-Type GIST Clinic
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3663836?pdf=render

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http://europepmc.org/articles/PMC3663836?pdf=render

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