The effect of Kagocel® on gene expression of Toll-like receptors of innate immunity in THP-1 human monocytes with different levels of differentiation

The effect of Kagocel® on gene expression of Toll-like receptors of innate immunity in THP-1 human monocytes with different levels of differentiation

Kagocel® is used in Russia for the treatment of viral infections. In terms of its chemical structure, Kagocel® active ingredient is a copolymer of gossypol polyphenol and carboxymethylcellulose. The study investigated antiviral and cytokine-inducing activity of Kagocel®, as well as its toxic effects...

Full description

Bibliographic Details
Main Authors:	T. M. Sokolova, V. V. Poloskov
Format:	Article
Language:	Russian
Published:	Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» 2021-07-01
Series:	Биопрепараты: Профилактика, диагностика, лечение
Subjects:	kagocel® preparation innate immunity tlr gene expression differentiation of thp-1 monocytes
Online Access:	https://www.biopreparations.ru/jour/article/view/341

Similar Items

REGULATION OF TLR/RLR GENE ACTIVITY AND SYNTHESIS OF CYTOKINES DURING PHORBOL MYRISTATE ACETATE (PMA)-INDUCED DIFFERENTIATION OF THP-1 MONOCYTES INTO MACROPHAGE-LIKE CELLS
by: T. M. Sokolova, et al.
Published: (2017-01-01)

Safety of the Russian antiviral drug Kagocel
by: T G Borovskaya
Published: (2017-11-01)

Gene Expression Pattern of Peyer’s Patch Lymphocytes Exposed to Kagocel Suggests Pattern-Recognition Receptors Mediate Its Action
by: Alexander A. Andreev-Andrievskiy, et al.
Published: (2021-08-01)

Dataset on the differentiation of THP-1 monocytes to LPS inducible adherent macrophages and their capacity for NO/iNOS signaling
by: Adem Ozleyen, et al.
Published: (2021-04-01)

Comparative Proteomic Analysis Reveals Varying Impact on Immune Responses in Phorbol 12-Myristate-13-Acetate-Mediated THP-1 Monocyte-to-Macrophage Differentiation
by: Sneha M. Pinto, et al.
Published: (2021-06-01)

Ulvan Activates Chicken Heterophils and Monocytes Through Toll-Like Receptor 2 and Toll-Like Receptor 4
by: Nathalie Guriec, et al.
Published: (2018-11-01)

The Transcriptional Network That Controls Growth Arrest and Macrophage Differentiation in the Human Myeloid Leukemia Cell Line THP-1
by: Iveta Gažová, et al.
Published: (2020-07-01)

egc Superantigens Impair Monocytes/Macrophages Inducing Cell Death and Inefficient Activation
by: Sofia Noli Truant, et al.
Published: (2020-01-01)

Pam3CSK4 Induces MMP-9 Expression in Human Monocytic THP-1 Cells
by: Fatema Al-Rashed, et al.
Published: (2017-04-01)

ROLE OF INNATE IMMUNITY FACTORS IN PERIODONTITIS PATHOGENESIS
by: L. V. Gankovskaya, et al.
Published: (2016-04-01)

Time course of changes in cytokines (IFN-γ, IFN-α, IL-18, TNF-α) in the treatment of moderate influenza A (H1N1) pdm09 (2013-2016) with oseltamivir (Tamiflu) and umifenovir (Arbidol) alone and in combination with Kagocel
by: A F Popov, et al.
Published: (2017-10-01)

Modulation of intracellular GSH in THP-1 cells during oxidative stress induced by AAPH
by: Brown, Erin
Published: (2009)

Personalised Profiling of Innate Immune Memory Induced by Nano-Imaging Particles in Human Monocytes
by: Giacomo Della Camera, et al.
Published: (2021-08-01)

Induction of Macrophage Function in Human THP-1 Cells is Associated with MAPK Signaling and Activation of MAP3K7 (TAK1) Protein Kinase
by: Erik eRichter, et al.
Published: (2016-03-01)

The TLR4-MyD88 Signaling Axis Regulates Lung Monocyte Differentiation Pathways in Response to Streptococcus pneumoniae
by: Rodrigo Sánchez-Tarjuelo, et al.
Published: (2020-09-01)

CRISPR-Cas9 Editing of Human Histone Deubiquitinase Gene USP16 in Human Monocytic Leukemia Cell Line THP-1
by: Iveta Gažová, et al.
Published: (2021-05-01)

Continuous But Not Pulsed Radiofrequency Current Generated by NeuroTherm NT500 Impairs Mitochondrial Membrane Potential in Human Monocytic Cells THP-1
by: Nishioka A, et al.
Published: (2020-07-01)

Induction of Innate Immune Memory by Engineered Nanoparticles in Monocytes/Macrophages: From Hypothesis to Reality
by: Paola Italiani, et al.
Published: (2020-10-01)

Vpx enhances innate immune responses independently of SAMHD1 during HIV-1 infection
by: Oya Cingöz, et al.
Published: (2021-02-01)

Eosinophil Activation by Toll-Like Receptor 4 Ligands Regulates Macrophage Polarization
by: Jiyoung Yoon, et al.
Published: (2019-12-01)

Severe inhibition of lipooligosaccharide synthesis induces TLR2-dependent elimination of Mycobacterium marinum from THP1-derived macrophages
by: Izabela Szulc-Kielbik, et al.
Published: (2017-11-01)

Corrigendum: Eosinophil Activation by Toll-Like Receptor 4 Ligands Regulates Macrophage Polarization
by: Jiyoung Yoon, et al.
Published: (2020-01-01)

Hemagglutinin protein of Peste des Petits Ruminants virus (PPRV) activates the innate immune response via Toll-like receptor 2 signaling
by: José M. Rojas, et al.
Published: (2021-01-01)

Innate Immune Cells: Monocytes, Monocyte-Derived Macrophages and Microglia as Therapeutic Targets for Alzheimer’s Disease and Multiple Sclerosis
by: Adham Fani Maleki, et al.
Published: (2019-07-01)

THE FUNCTION OF INTERLEUKIN-1 RECEPTOR ASSOCIATED KINASE 2 IN TOLL-LIKE RECEPTOR-MEDIATED SIGNALING
by: Wan, Youzhong
Published: (2010)

LXR Activation Induces a Proinflammatory Trained Innate Immunity-Phenotype in Human Monocytes
by: Yahya Sohrabi, et al.
Published: (2020-03-01)

Stimulation of monocytes by placental microparticles involves Toll-like receptors and nuclear factor kappa-light-chain-enhancer of activated B cells
by: Marianne Simone Joerger-Messerli, et al.
Published: (2014-04-01)

IN VITRO INTERACTION OF INFLUENZA VIRUS A(H1N1)pdm09 WITH MONOCYTIC MACROPHAGES: INDIVIDUAL RESPONSES OF TLR7 AND RIG1 RECEPTOR GENES
by: T. M. Sokolova, et al.
Published: (2017-12-01)

Cell Surface Expression of Endosomal Toll-Like Receptors—A Necessity or a Superfluous Duplication?
by: Matylda Barbara Mielcarska, et al.
Published: (2021-02-01)

Innate immunity and monocyte-macrophage activation in atherosclerosis
by: Davies Alun H, et al.
Published: (2011-04-01)

Immunomodulatory effect of structurally-characterized mushroom sclerotial polysaccharides isolated from Polyporus rhinocerus on human monoctyes THP-1
by: Chaoran Liu, et al.
Published: (2018-02-01)

Toll-like Receptor Sensing of Human Herpesvirus Infection
by: John A West, et al.
Published: (2012-10-01)

TLR expression in peripheral monocyte subsets of patients with idiopathic inflammatory myopathies: association with clinical and immunological features
by: Jiram Torres-Ruiz, et al.
Published: (2020-03-01)

EXPRESSION FEATURES OF TOLL-LIKE RECEPTOR 2 AND TOLL-LIKE RECEPTOR 4 IN CHILDREN WITH ASTHMA
by: L. V. Gankovskaya, et al.
Published: (2017-08-01)

Toll-Like Receptor 9 Agonists in Cancer
by: Karapetyan L, et al.
Published: (2020-10-01)

CHANGES OF INNATE IMMUNITY INDEXES IN SEVERE ASTHMA IN CHILDREN
by: L. V. Gankovskaya, et al.
Published: (2019-01-01)

Notch and TLR signaling coordinate monocyte cell fate and inflammation
by: Jaba Gamrekelashvili, et al.
Published: (2020-07-01)

Cotinine inhibits the pro-inflammatory response initiated by multiple cell surface Toll-like receptors in monocytic THP cells
by: Juhi Bagaitkar, et al.
Published: (2012-11-01)

Beyond defense: regulation of neuronal morphogenesis and brain functions via Toll-like receptors
by: Chiung-Ya Chen, et al.
Published: (2019-11-01)

In vitro estimation of the infectious potential of the enterococcal strain by an analysis of monocytes’ response to the formed biofilm
by: Tomasz Jarzembowski, et al.
Published: (2018-04-01)