Blocking LPA-dependent signaling increases ovarian cancer cell death in response to chemotherapy

Blocking LPA-dependent signaling increases ovarian cancer cell death in response to chemotherapy

The paradoxical role of reactive oxygen species in cell death versus cell survival establishes a delicate balance between chemotherapy efficacy and management of detrimental side effects. Normal proliferative signaling requires that cells remain inside a redox range that allows reversible protein ox...

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Bibliographic Details
Main Authors: LeAnn C. Rogers, Ryan R. Davis, Naveen Said, Thomas Hollis, Larry W. Daniel
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Redox Biology
Subjects:
Lysophosphatidic acid (LPA)
Ovarian cancer
Reactive oxygen species (ROS)
Chemotherapy
Taxol
Cisplatin
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231717309485

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http://www.sciencedirect.com/science/article/pii/S2213231717309485

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