Sustained Release of Decoy Wnt Receptor (sLRP6E1E2)-Expressing Adenovirus Using Gel-Encapsulation for Scar Remodeling in Pig Model

Sustained Release of Decoy Wnt Receptor (sLRP6E1E2)-Expressing Adenovirus Using Gel-Encapsulation for Scar Remodeling in Pig Model

An adenoviral vector (Ad) expressing a Wnt decoy receptor (sLRP6E1E2) is known to induce an anti-fibrotic effect by inhibiting Wnt signaling. We evaluated its effects in vivo using pig models and attempted to introduce an alginate gel-matrix system to prolong the effect of the Ad. Transduction effic...

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Bibliographic Details
Main Authors: Chae-Eun Yang, Sewoon Choi, Ju Hee Lee, Eun Hye Kang, Hyo Min Ahn, Tai Suk Roh, Chae-Ok Yun, Won Jai Lee
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
gene therapy
adenovirus
scar
alginate gel
decoy wnt receptor
pig model
Online Access:https://www.mdpi.com/1422-0067/21/6/2242

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