SIRT1 accelerates the progression of activity-based anorexia

SIRT1 accelerates the progression of activity-based anorexia

Anorexia nervosa is an eating disorder characterized by fear of gaining weight that can lead to serious complications. Here the authors show that inhibition of SIRT1 is protective against the onset and progression of anorectic behavior in an activity-based anorexia model, suggesting SIRT1 could be a...

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Main Authors: Timothy M. Robinette, Justin W. Nicholatos, Adam B. Francisco, Kayla E. Brooks, Rachel Y. Diao, Sandro Sorbi, Valdo Ricca, Benedetta Nacmias, Miguel A. Brieño-Enríquez, Sergiy Libert
Format: Article
Language:English
Published: Nature Publishing Group 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16348-9
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spelling doaj-e2920cd71a6c4de88a51804d31fe23602021-06-06T11:15:30ZengNature Publishing GroupNature Communications2041-17232020-06-0111111010.1038/s41467-020-16348-9SIRT1 accelerates the progression of activity-based anorexiaTimothy M. Robinette0Justin W. Nicholatos1Adam B. Francisco2Kayla E. Brooks3Rachel Y. Diao4Sandro Sorbi5Valdo Ricca6Benedetta Nacmias7Miguel A. Brieño-Enríquez8Sergiy Libert9Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh School of MedicineDepartment of Biomedical Sciences, Cornell UniversityDepartment of Biomedical Sciences, Cornell UniversityDepartment of Biomedical Sciences, Cornell UniversityDepartment of Biomedical Sciences, Cornell UniversityDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of FlorenceDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of FlorenceDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of FlorenceDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh School of MedicineDepartment of Biomedical Sciences, Cornell UniversityAnorexia nervosa is an eating disorder characterized by fear of gaining weight that can lead to serious complications. Here the authors show that inhibition of SIRT1 is protective against the onset and progression of anorectic behavior in an activity-based anorexia model, suggesting SIRT1 could be a potential therapeutic target.https://doi.org/10.1038/s41467-020-16348-9
collection DOAJ
language English
format Article
sources DOAJ
author Timothy M. Robinette
Justin W. Nicholatos
Adam B. Francisco
Kayla E. Brooks
Rachel Y. Diao
Sandro Sorbi
Valdo Ricca
Benedetta Nacmias
Miguel A. Brieño-Enríquez
Sergiy Libert
spellingShingle Timothy M. Robinette
Justin W. Nicholatos
Adam B. Francisco
Kayla E. Brooks
Rachel Y. Diao
Sandro Sorbi
Valdo Ricca
Benedetta Nacmias
Miguel A. Brieño-Enríquez
Sergiy Libert
SIRT1 accelerates the progression of activity-based anorexia
Nature Communications
author_facet Timothy M. Robinette
Justin W. Nicholatos
Adam B. Francisco
Kayla E. Brooks
Rachel Y. Diao
Sandro Sorbi
Valdo Ricca
Benedetta Nacmias
Miguel A. Brieño-Enríquez
Sergiy Libert
author_sort Timothy M. Robinette
title SIRT1 accelerates the progression of activity-based anorexia
title_short SIRT1 accelerates the progression of activity-based anorexia
title_full SIRT1 accelerates the progression of activity-based anorexia
title_fullStr SIRT1 accelerates the progression of activity-based anorexia
title_full_unstemmed SIRT1 accelerates the progression of activity-based anorexia
title_sort sirt1 accelerates the progression of activity-based anorexia
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-06-01
description Anorexia nervosa is an eating disorder characterized by fear of gaining weight that can lead to serious complications. Here the authors show that inhibition of SIRT1 is protective against the onset and progression of anorectic behavior in an activity-based anorexia model, suggesting SIRT1 could be a potential therapeutic target.
url https://doi.org/10.1038/s41467-020-16348-9
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