The Prodrug Approach: A Successful Tool for Improving Drug Solubility

The Prodrug Approach: A Successful Tool for Improving Drug Solubility

Prodrug design is a widely known molecular modification strategy that aims to optimize the physicochemical and pharmacological properties of drugs to improve their solubility and pharmacokinetic features and decrease their toxicity. A lack of solubility is one of the main obstacles to drug developme...

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Bibliographic Details
Main Authors: Daniela Hartmann Jornada, Guilherme Felipe dos Santos Fernandes, Diego Eidy Chiba, Thais Regina Ferreira de Melo, Jean Leandro dos Santos, Man Chin Chung
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Molecules
Subjects:
prodrug
solubility
water-soluble prodrugs
solubility of prodrugs
molecular modification
Online Access:http://www.mdpi.com/1420-3049/21/1/42

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