Melatonin and Rapamycin Attenuate Isoflurane-Induced Cognitive Impairment Through Inhibition of Neuroinflammation by Suppressing the mTOR Signaling in the Hippocampus of Aged Mice

Melatonin and Rapamycin Attenuate Isoflurane-Induced Cognitive Impairment Through Inhibition of Neuroinflammation by Suppressing the mTOR Signaling in the Hippocampus of Aged Mice

Melatonin exerts neuroprotective effects on isoflurane-induced cognitive impairment. However, the underlying mechanism has yet to be elucidated. The present study sought to determine if melatonin confers its beneficial effects by acting on mammalian target of rapamycin (mTOR) and attenuates the neur...

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Bibliographic Details
Main Authors: Hui Yuan, Guorong Wu, Xiaojie Zhai, Bo Lu, Bo Meng, Junping Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Aging Neuroscience
Subjects:
mTOR
melatonin
neuroinflammation
cognitive impairment
isoflurane
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2019.00314/full

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