Systems modeling predicts that mitochondria ER contact sites regulate the postsynaptic energy landscape

Abstract Spatiotemporal compartmentation of calcium dynamics is critical for neuronal function, particularly in postsynaptic spines. This exquisite level of Ca2+ compartmentalization is achieved through the storage and release of Ca2+ from various intracellular organelles particularly the endoplasmi...

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Bibliographic Details
Main Authors: A. Leung, D. Ohadi, G. Pekkurnaz, P. Rangamani
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:npj Systems Biology and Applications
Online Access:https://doi.org/10.1038/s41540-021-00185-7