Perturbation-response genes reveal signaling footprints in cancer gene expression

Deregulation of signalling is responsible for many cancer phenotypes. Leveraging available perturbation data, here the authors assess large-scale pathway activity patterns based on consensus downstream readout genes, enabling accurate prediction of the effects of mutations and small molecules.

Bibliographic Details
Main Authors:	Michael Schubert, Bertram Klinger, Martina Klünemann, Anja Sieber, Florian Uhlitz, Sascha Sauer, Mathew J. Garnett, Nils Blüthgen, Julio Saez-Rodriguez
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-02391-6

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spelling	doaj-e27e25be167a4eeb93814f6423e6cf862021-05-11T10:11:52ZengNature Publishing GroupNature Communications2041-17232018-01-019111110.1038/s41467-017-02391-6Perturbation-response genes reveal signaling footprints in cancer gene expressionMichael Schubert0Bertram Klinger1Martina Klünemann2Anja Sieber3Florian Uhlitz4Sascha Sauer5Mathew J. Garnett6Nils Blüthgen7Julio Saez-Rodriguez8European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome CampusInstitute of Pathology, Charité Universitätsmedizin BerlinInstitute of Pathology, Charité Universitätsmedizin BerlinInstitute of Pathology, Charité Universitätsmedizin BerlinInstitute of Pathology, Charité Universitätsmedizin BerlinMax Delbrück Center for Molecular Medicine (MDC), Berlin Institute for Medical Systems Biology/Berlin Institute of HealthWellcome Trust Sanger Institute, Wellcome Genome CampusInstitute of Pathology, Charité Universitätsmedizin BerlinEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome CampusDeregulation of signalling is responsible for many cancer phenotypes. Leveraging available perturbation data, here the authors assess large-scale pathway activity patterns based on consensus downstream readout genes, enabling accurate prediction of the effects of mutations and small molecules.https://doi.org/10.1038/s41467-017-02391-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Michael Schubert Bertram Klinger Martina Klünemann Anja Sieber Florian Uhlitz Sascha Sauer Mathew J. Garnett Nils Blüthgen Julio Saez-Rodriguez
spellingShingle	Michael Schubert Bertram Klinger Martina Klünemann Anja Sieber Florian Uhlitz Sascha Sauer Mathew J. Garnett Nils Blüthgen Julio Saez-Rodriguez Perturbation-response genes reveal signaling footprints in cancer gene expression Nature Communications
author_facet	Michael Schubert Bertram Klinger Martina Klünemann Anja Sieber Florian Uhlitz Sascha Sauer Mathew J. Garnett Nils Blüthgen Julio Saez-Rodriguez
author_sort	Michael Schubert
title	Perturbation-response genes reveal signaling footprints in cancer gene expression
title_short	Perturbation-response genes reveal signaling footprints in cancer gene expression
title_full	Perturbation-response genes reveal signaling footprints in cancer gene expression
title_fullStr	Perturbation-response genes reveal signaling footprints in cancer gene expression
title_full_unstemmed	Perturbation-response genes reveal signaling footprints in cancer gene expression
title_sort	perturbation-response genes reveal signaling footprints in cancer gene expression
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-01-01
description	Deregulation of signalling is responsible for many cancer phenotypes. Leveraging available perturbation data, here the authors assess large-scale pathway activity patterns based on consensus downstream readout genes, enabling accurate prediction of the effects of mutations and small molecules.
url	https://doi.org/10.1038/s41467-017-02391-6
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Perturbation-response genes reveal signaling footprints in cancer gene expression

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