Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases

Ferroptosis is a new form of programmed cell death characterized by intracellular iron-dependent accumulation of lipid peroxide and primarily associated with iron metabolism, glutathione-dependent pathway, and coenzyme Q10-dependent pathway. Recent studies demonstrate that ferroptosis is associated...

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Main Authors: Qingyun Tan, Yuying Fang, Qiong Gu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.657033/full
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spelling doaj-e27c7c3fe1ae4faa88443cb8490f21c42021-06-04T06:49:59ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-06-011210.3389/fphar.2021.657033657033Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System DiseasesQingyun TanYuying FangQiong GuFerroptosis is a new form of programmed cell death characterized by intracellular iron-dependent accumulation of lipid peroxide and primarily associated with iron metabolism, glutathione-dependent pathway, and coenzyme Q10-dependent pathway. Recent studies demonstrate that ferroptosis is associated with central nervous system (CNS) diseases, such as stroke, Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease. This review summarizes the key regulatory mechanisms of ferroptosis and its role in CNS diseases. These updates may provide novel perspective for the development of therapeutical agents against CNS diseases.https://www.frontiersin.org/articles/10.3389/fphar.2021.657033/fullferroptosislipid metabolismiron metabolismglutathione peroxidase 4coenzyme Q10central nervous system diseases
collection DOAJ
language English
format Article
sources DOAJ
author Qingyun Tan
Yuying Fang
Qiong Gu
spellingShingle Qingyun Tan
Yuying Fang
Qiong Gu
Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases
Frontiers in Pharmacology
ferroptosis
lipid metabolism
iron metabolism
glutathione peroxidase 4
coenzyme Q10
central nervous system diseases
author_facet Qingyun Tan
Yuying Fang
Qiong Gu
author_sort Qingyun Tan
title Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases
title_short Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases
title_full Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases
title_fullStr Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases
title_full_unstemmed Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases
title_sort mechanisms of modulation of ferroptosis and its role in central nervous system diseases
publisher Frontiers Media S.A.
series Frontiers in Pharmacology
issn 1663-9812
publishDate 2021-06-01
description Ferroptosis is a new form of programmed cell death characterized by intracellular iron-dependent accumulation of lipid peroxide and primarily associated with iron metabolism, glutathione-dependent pathway, and coenzyme Q10-dependent pathway. Recent studies demonstrate that ferroptosis is associated with central nervous system (CNS) diseases, such as stroke, Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease. This review summarizes the key regulatory mechanisms of ferroptosis and its role in CNS diseases. These updates may provide novel perspective for the development of therapeutical agents against CNS diseases.
topic ferroptosis
lipid metabolism
iron metabolism
glutathione peroxidase 4
coenzyme Q10
central nervous system diseases
url https://www.frontiersin.org/articles/10.3389/fphar.2021.657033/full
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