Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases
Ferroptosis is a new form of programmed cell death characterized by intracellular iron-dependent accumulation of lipid peroxide and primarily associated with iron metabolism, glutathione-dependent pathway, and coenzyme Q10-dependent pathway. Recent studies demonstrate that ferroptosis is associated...
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Frontiers Media S.A.
2021-06-01
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doaj-e27c7c3fe1ae4faa88443cb8490f21c42021-06-04T06:49:59ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-06-011210.3389/fphar.2021.657033657033Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System DiseasesQingyun TanYuying FangQiong GuFerroptosis is a new form of programmed cell death characterized by intracellular iron-dependent accumulation of lipid peroxide and primarily associated with iron metabolism, glutathione-dependent pathway, and coenzyme Q10-dependent pathway. Recent studies demonstrate that ferroptosis is associated with central nervous system (CNS) diseases, such as stroke, Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease. This review summarizes the key regulatory mechanisms of ferroptosis and its role in CNS diseases. These updates may provide novel perspective for the development of therapeutical agents against CNS diseases.https://www.frontiersin.org/articles/10.3389/fphar.2021.657033/fullferroptosislipid metabolismiron metabolismglutathione peroxidase 4coenzyme Q10central nervous system diseases |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qingyun Tan Yuying Fang Qiong Gu |
spellingShingle |
Qingyun Tan Yuying Fang Qiong Gu Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases Frontiers in Pharmacology ferroptosis lipid metabolism iron metabolism glutathione peroxidase 4 coenzyme Q10 central nervous system diseases |
author_facet |
Qingyun Tan Yuying Fang Qiong Gu |
author_sort |
Qingyun Tan |
title |
Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases |
title_short |
Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases |
title_full |
Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases |
title_fullStr |
Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases |
title_full_unstemmed |
Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases |
title_sort |
mechanisms of modulation of ferroptosis and its role in central nervous system diseases |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pharmacology |
issn |
1663-9812 |
publishDate |
2021-06-01 |
description |
Ferroptosis is a new form of programmed cell death characterized by intracellular iron-dependent accumulation of lipid peroxide and primarily associated with iron metabolism, glutathione-dependent pathway, and coenzyme Q10-dependent pathway. Recent studies demonstrate that ferroptosis is associated with central nervous system (CNS) diseases, such as stroke, Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease. This review summarizes the key regulatory mechanisms of ferroptosis and its role in CNS diseases. These updates may provide novel perspective for the development of therapeutical agents against CNS diseases. |
topic |
ferroptosis lipid metabolism iron metabolism glutathione peroxidase 4 coenzyme Q10 central nervous system diseases |
url |
https://www.frontiersin.org/articles/10.3389/fphar.2021.657033/full |
work_keys_str_mv |
AT qingyuntan mechanismsofmodulationofferroptosisanditsroleincentralnervoussystemdiseases AT yuyingfang mechanismsofmodulationofferroptosisanditsroleincentralnervoussystemdiseases AT qionggu mechanismsofmodulationofferroptosisanditsroleincentralnervoussystemdiseases |
_version_ |
1721398402319646720 |