Excess Polθ functions in response to replicative stress in homologous recombination-proficient cancer cells

Excess Polθ functions in response to replicative stress in homologous recombination-proficient cancer cells

DNA polymerase theta (Polθ) is a specialized A-family DNA polymerase that functions in processes such as translesion synthesis (TLS), DNA double-strand break repair and DNA replication timing. Overexpression of POLQ, the gene encoding Polθ, is a prognostic marker for an adverse outcome in a wide ran...

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Bibliographic Details
Main Authors: T. Goullet de Rugy, M. Bashkurov, A. Datti, R. Betous, L. Guitton-Sert, C. Cazaux, D. Durocher, J. S. Hoffmann
Format: Article
Language:English
Published: The Company of Biologists 2016-10-01
Series:Biology Open
Subjects:
Polθ
DNA polymerase theta
Synthetic lethality
High­-throughput screen
Online Access:http://bio.biologists.org/content/5/10/1485

Internet

http://bio.biologists.org/content/5/10/1485

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